The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Spring 2022 RFA: Therapeutic Pipeline Program Pre-Clinical, 2024(SUPPLEMENT) Targeting Phosphoinositides for Parkinson’s Disease Therapy
Study Rationale: Phosphoinositides (PIPs) are a group of lipids that build cell membranes and play critical roles in mechanisms that control cell’s growth, movement, propagation and death. Recent...
-
Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Alterations in DNA Repair Mechanisms in Parkinson’s Disease Neurons and their Correlation with Clinical Variables
Study Rationale: Preserving the fidelity of genetic information is essential for life. Consequently, all organisms have developed efficient systems for repairing DNA damage. One of the consequences of...
-
Parkinson’s Disease Therapeutics Pipeline Program, 2024A Translational Investigation of Drugs that Modulate Circadian Rhythm in Models of Parkinson’s Disease
Study Rationale: Recent studies suggest that sleep problems can worsen Parkinson’s disease (PD) by affecting chemicals in the brain and causing inflammation. It's also possible that sleep problems...
-
Parkinson’s Disease Therapeutics Pipeline Program, 2025Developing Novel Lysosome-based Translational Biomarkers and Ion-Channel Agonists as Therapeutics for Parkinson’s Disease
Study Rationale: Lysosomal dysfunction impairs cells’ ability to recycle their damaged components and is a primary contributor to the progression of Parkinson's disease (PD). TMEM175, a novel ion...
-
iPSC Phenotyping Environmental Exposure Program, 2024Phenotyping Environmental Exposure to Long-lasting Chemicals, Nanoplastics and Pesticides in iPSC Dopaminergic Neurons and Glia
Study Rationale: Of high priority is a need to understand the impact of pesticides, emerging long-lived chemicals, Per- and Polyfluoroalkyl Substances, and nanoplastics on neurons and glial cells and...
-
Spring 2022 RFA: Cellular Phenotyping in Human iPSCS from the PPMI Cohort, 2022Metabolic Phenotyping in PD Dopaminergic Neurons and Neuronal-glial Co-cultures Using High-throughput Single-cell Metabolomics and Lipidomics
Study Rationale: Recent studies have discovered metabolism to be altered in Parkinson’s disease with cells changing their bioenergetic pathways and accumulating metabolite markers. Every cell in our...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.