The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2012VPS35 as a Novel Target for Parkinson's Disease
Objective/Rationale:
Mutations in the VPS35 gene were recently identified as a cause of autosomal dominant familial Parkinson's disease (PD). How mutations in VPS35 precipitate the demise of...
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Critical Challenges in PD: Postural Instability and Gait Dis, 2012Targeted Cognitive Training Program for Freezing of Gait
Promising Outcomes of Original Grant:
In our original study we investigated the processes underlying the freezing phenomenon in PD. In this work we found symptoms of freezing of gait (FOG) could be... -
Therapeutics Development Initiative, 2011Next Generation Parkinson's Disease Treatment through Steering Brain Stimulation (NEXT)
Objective/Rationale:
Deep Brain Stimulation (DBS) can provide a radical improvement in the quality of life of Parkinson’s patients. However, it is a complex procedure with a large incidence of... -
Therapeutics Development Initiative, 2011Characterization of NPT001-mediated Alpha-Synuclein Disaggregation and Clearance
Objective/Rationale:
Abnormal accumulation of alpha-synuclein in the brain is associated with toxicity and disease progression in Parkinson’s and other neurodegenerative diseases. NPT001 has been... -
LRRK2, 2011fMRI of First Degree Relatives of LRRK2 Positive Parkinson's Disease Patients
Objective/Rationale:
First, to study the effect of the presence of the LRRK2 G2019S mutation on brain activation patterns in PD patients who recently converted into a diseased state by comparing... -
LRRK2, 2011Increased Sensitivity to the Loss of Nigrostriatal Dopamine Following Progressive MPTP Treatment in LRRK2 Mutant Small Models
Objective/Rationale:
It is known that a mutation of specific gene, called LRRK2, increases the risks of developing Parkinson’s disease in humans. The specific objective of this proposal is to...
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Our funding programs support basic, translational and clinical research from academia and industry.