The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Resource: Utilizing DATATOP Biospecimens, 2011Validation of Alpha-synuclein Oligomers as Biomarker for Parkinson’s Disease
Objective/Rationale:
We have reported recently higher levels of α-synuclein oligomers species in cerebral spinal fluid (CSF) from patients clinically diagnosed with Parkinson’s disease (PD) versus... -
Resource: Utilizing DATATOP Biospecimens, 2011C-type Natriuretic Peptide (CNP): A Putative Biomarker of Neuronal Damage in Parkinson's Disease
Objective/Rationale:
CNP is a peptide produced by brain tissues where it acts to promote growth of nerve cells and their connections. Recent research in healthy humans has identified high... -
Defining Cognitive Phenotypes of Parkinson’s Disease, 2011The Relationship Between Cognitive Phenotypes of PD with Visual Hallucinations and 5HT2A Receptors in the Inferotemporal Cortex
Objective/Rationale:
The project aims to understand the mechanisms underlying cognitive deficits that are associated with visual hallucinations (VH) in Parkinson’s disease (PD). We have previously... -
Rapid Response Innovation Awards, 2011Development of Dopaminergic Cell Line Models of Alpha-synuclein Expression for High-throughput Drug Screenings and Monitoring of Alpha-synuclein Expression
Objective/Rationale:
Parkinson’s disease (PD) affects millions of people in the United States, and it is caused by the death of neurons that produce dopamine. A large body of experimental evidence... -
MJFF Research Grant, 2011Development of Hsf1 Effectors as Parkinson's Disease Therapeutics
Objective/Rationale:
This project focuses on the development of small molecule therapeutics to treat Parkinson’s disease by advancing lead compounds that elevate the abundance of protein chaperones.... -
Rapid Response Innovation Awards, 2011Transport and Transfer of Misfolded Alpha-synuclein in Neurons
Objective/Rationale:
Alpha-synuclein is a protein found in human neurons that can adopt a toxic form whose spread may be responsible for Parkinson’s disease. We showed that toxic alpha-synuclein is...
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Our funding programs support basic, translational and clinical research from academia and industry.