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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    First-in-human Phase 1a Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending doses of SB-0110 after Oral Administration in Healthy Subjects

    Study Rationale: Although levodopa is an effective treatment for Parkinson’s disease (PD), it has a debilitating on-target side effect of dyskinesia. An optimal PD therapy would selectively activate...

  • Freezing of Gait Program, 2024
    Use of Neuromodulation to Relieve Gait Freezing in Parkinson’s Disease

    Study Rationale: Almost all individuals with Parkinson’s disease (PD) develop episodes of freezing of gait, which is a sudden inability to take a step while walking. Gait freezing can cause falls that...

  • Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024
    Study of Multiple Air Pollutants in Parkinson’s Disease (MAP-PD)

    Study Rationale: Chemicals in our environment, including some air pollutants, likely contribute to the development of Parkinson’s disease (PD). However, relatively few chemicals have been identified...

  • Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024
    Investigating the Effects of Pesticide Exposure on Immune System Function in Parkinson’s Disease

    Study Rationale: Although it is well known that exposure to environmental substances, including pesticides, contributes considerably to Parkinson’s disease (PD), the mechanisms are largely unexplored...

  • ASAP CRN Competitive Renewal Opportunity, 2024
    Studying the Pathogenesis of Parkinson’s Disease Via Single-cell Analysis of Human Brain and Gut Cells: A Basis for Clinical Translation
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    Study Rationale: More than 100 regions of the chromosomes that we inherit from our parents show differences in DNA sequence between people with and without Parkinson’s disease (PD). Furthermore, as we...

  • ASAP CRN Competitive Renewal Opportunity, 2024
    Identifying Mechanisms that Overwhelm Protein and Organelle Quality Control in Parkinson’s Disease
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    Study Rationale: Abnormal protein aggregation and prion-like aggregate spreading are hallmarks of the degenerative cascades of sporadic and familial Parkinson’s disease (PD). These toxic aggregates...

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