The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2010Down-regulation of GDNF Signaling in the Alpha-synuclein Model of PD: Implications for the Use of GDNF in Neuroprotective Therapy
Objective/Rationale:
GDNF is currently the most effective, and best studied, survival factor acting on dopamine neurons (the neurons that die in Parkinson´s disease, PD). Infusion of GDNF into the... -
Rapid Response Innovation Awards, 2010Identification of Small-molecule Stabilizers of DJ-1: Biophysical and Cellular Validation
Objective/Rationale:
The goal of our project is to develop an approach to treat PD by stabilizing wild-type dimeric DJ-1 with a small molecule. We hypothesize that this approach will lead to an... -
Rapid Response Innovation Awards, 2010MicroRNAs as Biomarkers for Parkinson's Disease; A Comparison of CSF and Blood
Objective/Rationale:
We, and many other groups, hypothesize that miRNAs have the potential to be selective and sensitive diagnostic indicators for Parkinson’s disease. The focus of this project is to... -
Target Validation, 2010Validation of FKBP Inhibitors to Target Alpha-synuclein Pathology in Pre-clinical Model Brain
Objective/Rationale:
FK506 Binding Proteins (FKBPs) are enzymes that play a role in protein folding. FKBPs are highly expressed in human brain and are thought to be involved in neurodegenerative... -
Target Validation, 2010Does the Ubiquitin Ligase, Nedd4, Protect Against Alpha-Synucleinopathy?
Objective/Rationale:
The cellular mechanisms that normally limit accumulation of alpha-synuclein are unclear. We have found that the enzyme, Nedd4, tags alpha-synuclein for destruction in lysosomes... -
Rapid Response Innovation Awards, 2010Genetic Dissection of Parkinson's Disease Vulnerable Dopaminergic Neurons Population
Objective/Rationale:
There is a clear heterogeneity in the susceptibility of dopamine neurons to Parkinson’s disease. Indeed, neurons of the substancia nigra ventral tier are specifically lost in...
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