The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LEAPS, 2018Studying LRRK2 Mutations as a Possible Cause of Waste Buildup in Nerve Cells
Study Rationale:
Health and longevity of brain cells depends on the efficiency of their waste removal process, known as autophagy or self-eating. Cells use autophagy to get rid of unwanted protein... -
Target Advancement Program, 2018Validation of CD4 T Cell Dependent Neurotoxicity in an Alpha-Synuclein Model of Parkinson's Disease
Study Rationale:
Microglia, an immune cell in the brain, takes up unneccessary alpha-synuclein proteins and passes it on to the major histocompatibility complex (MHCII). This involves an interaction... -
Therapeutic Pipeline Program, 2018Dual Leucine Zipper Kinase Inhibitors for Parkinson's Disease
Study Rationale:
There are no therapies that slow down the loss of brain cells affected by Parkinson's disease. Prior research suggests that dual leucine zipper kinase (DLK) regulates stress response... -
Research Grant, 2018Peripheral Inflammatory Cytokine Profiling in Parkinson's Disease
Study Rationale:
A growing body of research suggests that inflammation contributes to Parkinson's disease. However, the stages in the disease process that inflammation is prevalent and important are... -
Research Grant, 2018Conformational Changes in the Activation of the Ubiquitin Ligase Parkin
Study Rationale:
Parkin is an enzyme that modifies proteins on mitochondria in response to damage. In previous MJFF-funded research, we examined how Parkin changes its conformation as it goes from an... -
Mitochondrial Biomarkers Program, 2018Novel Mitochondrial Biomarkers in Genetically Stratified Parkinson's Disease Patients
Study Rationale:
Parkinson's disease has many causes and can be thought of as an umbrella term for patients with a diverse set of experiences. Research suggest that dysfunction of mitochondria (e.g...
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Our funding programs support basic, translational and clinical research from academia and industry.