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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Proof-of-Concept Testing of PD Therapeutics, 2022
    Therapeutic Targeting of Mitochondrial Biogenesis to Address Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) is a complex disorder involving the degeneration of specific brain cells that lead to severe impairments in movement and cognition. Although the exact cause...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Assessment of IRL757 for the Treatment of Apathy in Parkinson's Disease

    Study Rationale: People with Parkinson’s disease (PD) frequently develop a loss of motivation and initiative. Such apathy can be burdensome for patients and their families and caregivers and is...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Investigation of a Novel Therapeutic Approach for Non-motor Symptoms of Parkinson’s Disease

    Study Rationale:                  

    Parkinson's disease (PD) is characterized by both motor symptoms and non-motor symptoms. While progress has been made in addressing motor symptoms, non-motor...

  • Fast Track, 2001
    PET Neuroimaging Study of the Brain Serotonin Transporter in Parkinson's Disease: Relationship to Clinical Depression

    Approximately 40% of patients with Parkinson's disease (PD) suffer from depression, which in many cases is more disabling than the impairment of motor function. Since the original discovery by Oleh...

  • LRRK2, 2011
    fMRI of First Degree Relatives of LRRK2 Positive Parkinson's Disease Patients

    Objective/Rationale:
    First, to study the effect of the presence of the LRRK2 G2019S mutation on brain activation patterns in PD patients who recently converted into a diseased state by comparing...

  • Target Validation, 2011
    Preferential Targeting of Subpopulations of 5-HT1A Receptors

    Objective/Rationale:
    Although Parkinson's disease (PD) is primarily caused by dopamine dysfunction, function of serotonin (another neurotransmitter) is also affected. This suggests that serotonergic...

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