The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2018Genotypic Influences on Network Progression in Parkinson’s Disease
Study Rationale:
Parkinson’s disease patients with mutations in the glucocerebrosidase (GBA) gene tend to have a more aggressive disease course. GBA pathways may therefore constitute a discrete target... -
GBA Biology and Therapies, 2018Sphingolipid and Alpha-synuclein Interactions
Study Rationale:
In Parkinson’s, a normal cellular protein called alpha-synuclein begins to fold incorrectly (misfold), and this has a central role in the development of the disease. Our research... -
GBA Biology and Therapies, 2018Molecular Imaging and Computer Typing in GBA-PD and Asymptomatic GBA-mutation Carriers
Study Rationale:
People who have a mutation in the GBA gene have a higher risk of developing Parkinson’s disease (PD) and, if they have PD, are more likely to have cognitive decline and dementia... -
GBA Biology and Therapies, 2018GBA Defects Cause C5a-C5aR1-induced Neurodegeneration in Parkinson’s Disease
Study Rationale:
People with GBA-associated Parkinson’s disease (PD) lack enzymes that break down certain fatty molecules (e.g., glucosylceramide), preventing their cells from shedding these waste... -
GBA Biology and Therapies, 2018Live Cell Image-based Screening and Validation of Glucocerebrosidase Activators
Study Rationale:
Changes in the gene GBA that cause malfunction of a protein known as glucocerebrosidase (GCase) are found in about 10 percent of Parkinson’s disease (PD) patients. Even those PD... -
GBA Biology and Therapies, 2018Role of GBA in Mitochondrial Antigen Presentation
Study Rationale:
Parkinson’s disease is caused by the death of dopaminergic neurons in the brain. We propose that the immune system plays a key role in the death of dopaminergic neurons during PD via a...
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