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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2013
    Exenatide as a Treatment for Patients with Parkinson’s Disease

    Objective/Rationale:             
    Laboratory data from several teams have indicated potential beneficial effects of the drug Exenatide on the survival of dopamine cells. In a small group of patients...

  • MJFF Research Grant, 2011
    Ghrelin Concentrations in CSF and Corresponding Serum Samples in PD Patients and Controls

    Objective/Rationale:
    The aim of this study is to establish a valid method for measuring ghrelin concentrations in human cerebrospinal fluid samples. Ghrelin is an appetite-stimulating hormone with...

  • Non-pharmacological Interventions for Gait and Balance, 2019
    Protective Step Training in People with Parkinson's Disease and Postural Disturbances

    Study Rationale:
    Falls are a common and challenging symptom of Parkinson's disease. The ability to execute a quick and effective movement after a loss of balance (e.g., a "protective step") may reduce...

  • Research Grant, 2020
    Alpha-synuclein Toxicity in LRRK2 Knock-in Models and Rescue by LRRK2 Silencing

    Study Rationale:
    Gene mutations that alter the function of the LRRK2 protein are known to increase the risk of developing Parkinson’s disease (PD). One of the pathological hallmarks of PD is the...

  • Target Advancement Program, 2021
    Sex-based Modulation of Neuromelanin-linked Parkinson’s Disease Pathology

    Study Rationale:
    Parkinson’s disease (PD) is more common in men than in women, and men with PD exhibit earlier onset, faster progression, more severe motor symptoms and more frequent cognitive decline...

  • Research Grant, 2022
    Development And Validation Of A Miro1 Biomarker Assay Using White Blood Cells

    Study Rationale: The mitochondrial protein Miro1 fails to be degraded and this defect impairs mitophagy in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms...

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