The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2024Virtual Screening and Biochemical Confirmation of Small Molecule Activators of ATP10B
Study Rationale: Disruption of lysosomal glucosylceramide (GluCer) homeostasis is a key risk factor in Parkinson’s disease. ATP10B, a lysosomal GluCer exporter, has been linked to Parkinson’s through...
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Therapeutic Pipeline Program, 2024Integrin CLOAKs as Novel Oral Therapeutics for Parkinson’s Disease
Study Rationale: Increased neuroinflammation promotes neuron injury and loss (neurodegeneration) and drives progression of Parkinson’s Disease (PD), suggesting that controlling neuroinflammation is an...
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Summer 2025 RFP: Accelerating Biological Understanding and Translational Approaches for PD Program - Biomarkers, 2025EV-PREDICT: Identifying Early Biomarkers for Parkinson’s Disease in Blood-derived Neuronal Vesicles
Study Rationale: Parkinson’s disease (PD) is a common and growing brain disorder that currently has no cure and is difficult to diagnose early. A key feature of PD is the abnormal buildup of a protein...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025SUPPLEMENT: IRL757 for the Treatment of Apathy in Parkinson's Disease
Study Rationale: People with PD frequently develop a loss of motivation and initiative. This phenomenon is called apathy and can be a very burdensome symptom of PD, affecting not only the patient but...
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Research Grant, 2025Potent Inhibitors of Deubiquitinating Enzyme USP14 as Inducers of Parkin-independent Mitophagy
Study Rationale: We are working on a small, drug-like compound that has potential therapeutic application in Parkinson's disease. This drug-like compound specifically inhibits a protein in the cell...
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Spring 2025 RFA: Molecular MRI Biomarker Program, 2025Novel Molecular Magnetic Resonance Imaging to Visualize and Quantify Impaired Brain Mitochondrial Bioenergetics in Parkinson's Disease
Study Rationale: Parkinson's disease (PD) is a neurodegenerative disease that affects the quality of life of more than one million people in the United States alone. Abnormal brain energy metabolism...
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Our funding programs support basic, translational and clinical research from academia and industry.