The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Generation and Characterization of Mice with Inducible and Cell-Type Specific Interruption ofGDNF Signaling
The primary goal of this proposal is the generation of two powerful and innovative conditional mouse knockout strains to interrupt GDNF signaling. We propose to conditionally knock out the GDNF...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Small Molecules That Promote Regeneration of Dopaminergic Neurons from Human Neural Stem Cells
For a better understanding of the signaling pathways that instruct neural precursor cells to differentiate into dopaminergic (DA) neurons (which are lost in the brain of Parkinson's Disease patients)...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2005Engineering Midbrain Dopamine Neurons by Forced Expression of a Novel Dopamine Cell Determinant in Pre-Clinical Model Embryonic Stem Cells
Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Role of Pitx3 in the Development of Midbrain DA Neurons
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is caused by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Molecular...
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Cell Line, 2002Development of a Stem Cell Replacement Therapy for Parkinson's Disease: Induction of Midbrain DA Neurons from ES Cells
In the present project three groups at the Karolinska Institute join forces in order to: 1) Identify molecular players capable of inducing a midbrain dopaminergic (DA) phenotype. We previously found...
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Cell Line, 2002Generation of Functional Dopamine Neurons of Human Origin for Grafting in Parkinson's Disease
The project will use multipotent neural stem cells as starting material. These cells, which reside in the central nervous system, will be isolated from the developing brains of five- to eight-week-old...
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Our funding programs support basic, translational and clinical research from academia and industry.