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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Advancement Program, 2021
    Use of Therapeutic Nanoparticles to Inhibit Toxic Aggregation of Alpha-Synuclein

    Study Rationale:
    A hallmark of Parkinson’s disease (PD) is the abnormal accumulation of clumps of alpha-synuclein in nerve cells. These improperly folded protein clumps contribute to the symptoms of...

  • Research Grant, 2023
    Leveraging Gene Expression Data to Redefine Parkinson’s Disease and the Pathways Driving Disease in Different Individuals

    Study Rationale: People with Parkinson’s disease (PD) share some common problems, such as stiffness, slowness of movement and tremors. However, these symptoms vary in severity, and individuals often...

  • Freezing of Gait Program, 2024
    Use of Neuromodulation to Relieve Gait Freezing in Parkinson’s Disease

    Study Rationale: Almost all individuals with Parkinson’s disease (PD) develop episodes of freezing of gait, which is a sudden inability to take a step while walking. Gait freezing can cause falls that...

  • Developing and Validating Web-Based Clinical Assessments for, 2008
    Online Motor and Cognitive Analysis System

    Objective/Rationale:
    Despite advances in treatment approaches to Parkinson’s disease over the past 20 years, patient assessment methods have advanced little during this same period. Therefore, a...

  • Target Validation, 2011
    Preferential Targeting of Subpopulations of 5-HT1A Receptors

    Objective/Rationale:
    Although Parkinson's disease (PD) is primarily caused by dopamine dysfunction, function of serotonin (another neurotransmitter) is also affected. This suggests that serotonergic...

  • Research Grant, 2021
    Bipolar Disorder and Parkinson’s Disease

    Study Rationale:
    Mood disorders are common in people with Parkinson’s disease (PD) and, in many cases, precede motor symptoms and diagnosis by years. The relationship between bipolar disorder and PD...

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