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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Priority Biology, 2021
    Use of the Lipid BMP as a Surrogate Marker for LRRK2 and GCase Activity

    Study Rationale:
    Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD) and offer promising targets for the development of PD therapies. Identification of a...

  • Priority Biology, 2021
    Efficacy of PRKN Gene Delivery toward Mitigation of Alpha-synuclein-induced Degeneration

    Study Rationale:
    Genetic mutations that cause the functional loss of the PRKN gene and its corresponding protein, parkin, can cause early-onset Parkinson’s disease (PD). Regardless of the cause...

  • Aligning Science Across Parkinson's, 2021
    Engineering Research-enabling Cells to Fuel Mechanistic Studies of Parkinson’s Disease
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    Study Rationale:  
    Induced pluripotent stem cells (iPSCs) have become widely used in the research community to investigate how mutations found in genetic studies of Parkinson’s disease (PD) alter the...

  • Therapeutic Pipeline Program, 2021
    Understand Me for Life: An Intelligibility App for Parkinson's Disease

    Study Rationale:
    Approximately 90% of people with Parkinson’s develop speech and language problems over the course of the disease, and more than half of these speakers experience problems with...

  • Research Grant, 2021
    Parkinson’s Disease Patient Report of Problems (PD-PROP) Curation

    Study Rationale:
    What people with Parkinson’s feel and experience about their disease, and how it affects their lives, is of paramount importance to their care and participation in research. The...

  • Priority Biology, 2021
    Studying the Properties of Alpha-Synuclein Aggregates Amplified from Human Cerebrospinal Fluid

    Study Rationale:
    Aggregates of the protein alpha-synuclein, which accumulate in the brains of people with Parkinson’s disease (PD), can also be detected in biofluids like cerebrospinal fluid (CSF)...

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