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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2021
    Codevelopment of Small-molecule Regulators of Miro1 for the Treatment of Parkinson’s Disease and a GLP Clinical Biomarker Assay

    Study Rationale:    
    The mitochondrial protein Miro1 is elevated in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms. The high level of Miro1 is a pathogenic...

  • Research Grant, 2021
    Genotyping of Lymphoblastoid Cell Lines from Familial and Sporadic Parkinson’s Disease

    Study Rationale:
    Our previous studies show deficits in a cell activity called centrosome cohesion in cells from people with Parkinson’s disease (PD) and a LRRK2 mutation. These deficits are reverted by...

  • Priority Biology, 2021
    Developing New Therapeutic Drugs for Parkinson’s in Human Stem Cell Neurons

    Study Rationale:
    Neurons derived from stem cells from people with Parkinson’s disease offer an opportunity to perform drug and target discovery. We completed a screen of 4,000 drug compounds in such...

  • Therapeutic Pipeline Program, 2021
    Brain-penetrating Antisense Oligonucleotide to Down-regulate Alpha-synuclein

    Study Rationale:
    Antisense oligonucleotides (ASOs) are a new type of therapeutic that have promise for treating Parkinson’s disease. They act by modifying the production of specific proteins, such as...

  • Research Grant, 2020
    California Parkinson’s Disease Registry

    Study Rationale:    
    This project will support operations and enhancement of the California Parkinson’s Disease Registry (CPDR) for one year. CPDR captures and stores information on all Parkinson’s...

  • Priority Biology, 2020
    Effects of LRRK2 Variants on GCase Activity in iPSC-derived Dopamine Neurons and Microglia

    Study Rationale:
    There is contradictory evidence on whether the LRRK2 and GBA genes, and the proteins that they encode, interact in their effects on Parkinson’s disease. Some studies suggest that LRRK2...

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Our funding programs support basic, translational and clinical research from academia and industry.

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