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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • 2022: Accelerated Therapeutics Program, 2022
    Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies

    Study Rationale: LBT-3627 is a disease-modifying therapeutic candidate that has been shown to reduce brain inflammation and immune imbalance in preclinical models of Parkinson's disease (PD). A recent...

  • Research Grant, 2022
    Developing a Method for Detecting Alpha-synuclein in the Acidic Cell Compartments in Which It Accumulates

    Study Rationale: The protein alpha-synuclein forms harmful clusters or aggregates that can kill neurons in the brains of people with Parkinson’s disease (PD). Neurons attempt to eliminate these clumps...

  • Fall 2021 RFP: Expanding Biological Understanding of PD, 2022
    Identifying a Molecular Signature of DNA Damage in the Blood Cells of People with Parkinson’s Disease

    Study Rationale: The instructions needed to govern the function of living things are stored in their cells’ DNA. In cell types that divide, such as blood or skin, DNA checked for damage and repaired...

  • Fall 2021 RFA: Promoting Diversity, Equity and Inclusion in Parkinson’s Disease Research, 2022
    Identifying Barriers and Motivators Associated with Access to Care and Participation in Genetic Research Studies for Parkinson's Disease among Asian Americans

    Study Rationale: Clinicians have observed that Asian Americans are older and have had symptoms for a longer period of time than Whites when they are diagnosed with Parkinson’s disease (PD). In...

  • Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022
    Use of Itaconate to Improve Metabolic Regulation in Parkinson's Disease

    Study Rationale: In people with Parkinson’s disease (PD), chronic inflammation and metabolic reprogramming triggers neuronal cell death. Impaired function of the proteins involved in cellular...

  • Fall 2021 RFP: Expanding Biological Understanding of PD, 2022
    Exploring How Mutations in Genes Associated with Parkinson’s Disease Alter the Activity of Other Genes

    Study Rationale: Population studies have identified genetic changes that raise an individual’s risk of developing Parkinson’s disease (PD). However, this information doesn't help people if we don’t...

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