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The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Biosample Use Program, 2020CSF RT-QuIC Alpha-Synuclein Amplification in LRRK2-Parkinson’s Disease
Study Rationale:
Parkinson’s disease caused by genetic mutations in the gene called leucine rich repeat kinase 2 (LRRK2) is clinically indistinguishable from idiopathic Parkinson’s disease, in which... -
Aligning Science Across Parkinson's, 2020Activation of Transposable Elements as a Trigger of Neuroinflammation in Parkinson’s Disease
Study Rationale:
Inflammation is a common event in Parkinson’s disease (PD), but its source remains unclear. There are many candidates that could cause inflammation in the nervous system. One likely... -
Aligning Science Across Parkinson's, 2020Mechanisms of Mitochondrial Damage Control by PINK1 and Parkin
Study Rationale:
Mitochondria are tiny power-generating stations within all cells, including neurons. They are vital energy producers, but when things go wrong, they can spew toxic materials and sicken... -
Aligning Science Across Parkinson's, 2020In Vivo Approach to Elucidate the Pathobiology of Parkinson’s-associated Genes Using Human Diseased Neurons
Study Rationale:
Several genes are known to be associated with Parkinson’s disease, although how they impact the disease process is not fully understood. Here we will use stem cells from patients in... -
Aligning Science Across Parkinson's, 2020Role of PD-related Proteins as Drivers of Disease through Modulation of Innate and Adaptive Immunity
Study Rationale:
The hallmark motor impairments in Parkinson’s disease patients are due to the progressive loss of a special type of neuron in the brain using the chemical messenger dopamine. The... -
Aligning Science Across Parkinson's, 2020Impaired Integration of Organelle Function in Parkinson’s Disease
Study Rationale:
Geneticists have made great progress in identifying gene mutations that either cause Parkinson’s or increase disease risk. The critical next step is to determine how some of these...
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Our funding programs support basic, translational and clinical research from academia and industry.