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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2021
    Assessing the Potential of Low-Dose Carbon Monoxide Therapy in Parkinson’s Disease

    Study Rationale:
    Although carbon monoxide (CO) is commonly considered harmful, a growing body of research suggests that low doses of CO can stimulate physiologic processes that may protect against...

  • Expanding Biological Understanding of PD, 2021
    Assessing Inhibition of NLRP3 to Reduce Brain Inflammation in Parkinson’s Disease

    Study Rationale: 
    Recent studies indicate that brain inflammation caused by activation of a protein complex called the NLRP3 inflammasome worsens Parkinson’s disease (PD). Although multiple drugs...

  • Analysis of Patient-Reported Outcomes from Fox Insight, 2021
    Characterizing Impairment Trajectories in People with Parkinson’s Disease

    Study Rationale: 
    Little is known about what causes individuals with Parkinson’s disease (PD) to develop symptoms, much less the genetic and non-genetic factors that influence these changes. In most...

  • Analysis of Patient-Reported Outcomes from Fox Insight, 2021
    Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease

    Study Rationale:
    We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This...

  • Target Advancement Program, 2021
    Developing a Protein Quality Control Mechanism as a Novel Therapy for Parkinson’s Disease

    Study Rationale:
    Parkinson’s disease is a disorder of protein misfolding and aggregation. It is characterized by the presence of Lewy bodies and Lewy neurites: aberrant intracellular structures...

  • Analysis of Patient-Reported Outcomes from Fox Insight, 2021
    Using Risk Scores to Link Molecular Mechanisms to Clinical Outcomes in Parkinson's Disease

    Study Rationale:    
    The symptoms and course of Parkinson’s disease (PD) show remarkable variation from one person to another, indicating differences in the underlying disease process that may also...

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