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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Access to Data and Biospecimens, 2020
    Association of Repetitive DNA Elements in Parkinson’s Disease Risk and Progression

    Study Rationale:
    Repetitive DNA elements such as “jumping genes” were previously considered ‘junk DNA’. However, it is now known that these elements are involved in the development of several diseases...

  • Research Grant, 2019
    Long-acting GM-CSF Fusion Protein (PDM608) for the Treatment of Parkinson’s Disease

    Study Rationale:
    Emerging evidence suggests that the modulating the peripheral immune system can be a powerful disease-modifying approach for the treatment of Parkinson's disease (PD). We have...

  • Therapeutic Pipeline Program, 2019
    Oligomeric Alpha-synuclein-specific Antibody-based Gene Therapy

    Study Rationale:
    Alpha-synuclein is the primary component of Lewy bodies, the hallmark of Parkinson’s disease (PD). In particular, soluble aggregates of alpha-synuclein, also referred to as oligomers,...

  • Astrocyte Biology in Parkinson's Disease, 2019
    Astrocyte Gene Expression in Parkinson’s Interrogated Using Single Cell Nuclear RNA Sequencing

    Study Rationale:
    Astrocytes are one of the major non-neuron cell types in the brain and control many neurological processes. They are likely to be changed in Parkinson’s disease (PD) and may...

  • Astrocyte Biology in Parkinson's Disease, 2019
    Characterization of Astrocytes in Aging and Lewy Body Pathology

    Study Rationale:
    Astrocytes are brain cells with crucial roles, including communication between nerve cells, clearance of unwanted material, and response to injury. It has been suggested that astrocyte...

  • Astrocyte Biology in Parkinson's Disease, 2019
    Control of Astrocyte Function by LRRK2

    Study Rationale:
    Mutations in the LRRK2 gene are known to cause Parkinson’s disease (PD), but how mutations in this gene lead to neuron death is not yet known. Astrocytes, which are brain cells that su...

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