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The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2021Codevelopment of Small-molecule Regulators of Miro1 for the Treatment of Parkinson’s Disease and a GLP Clinical Biomarker Assay
Study Rationale:
The mitochondrial protein Miro1 is elevated in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms. The high level of Miro1 is a pathogenic... -
Research Grant, 2021Genotyping of Lymphoblastoid Cell Lines from Familial and Sporadic Parkinson’s Disease
Study Rationale:
Our previous studies show deficits in a cell activity called centrosome cohesion in cells from people with Parkinson’s disease (PD) and a LRRK2 mutation. These deficits are reverted by... -
Priority Biology, 2021Developing New Therapeutic Drugs for Parkinson’s in Human Stem Cell Neurons
Study Rationale:
Neurons derived from stem cells from people with Parkinson’s disease offer an opportunity to perform drug and target discovery. We completed a screen of 4,000 drug compounds in such... -
Therapeutic Pipeline Program, 2021Brain-penetrating Antisense Oligonucleotide to Down-regulate Alpha-synuclein
Study Rationale:
Antisense oligonucleotides (ASOs) are a new type of therapeutic that have promise for treating Parkinson’s disease. They act by modifying the production of specific proteins, such as... -
Research Grant, 2020California Parkinson’s Disease Registry
Study Rationale:
This project will support operations and enhancement of the California Parkinson’s Disease Registry (CPDR) for one year. CPDR captures and stores information on all Parkinson’s... -
Priority Biology, 2020Effects of LRRK2 Variants on GCase Activity in iPSC-derived Dopamine Neurons and Microglia
Study Rationale:
There is contradictory evidence on whether the LRRK2 and GBA genes, and the proteins that they encode, interact in their effects on Parkinson’s disease. Some studies suggest that LRRK2...
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Our funding programs support basic, translational and clinical research from academia and industry.