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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Cognition Biomarkers, 2014
    miRNA Markers of Cognition

    In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs...

  • Cognition Biomarkers, 2013
    Alpha-synuclein and Cognitive Decline in Parkinson’s Disease

    Variability in the SNCA gene (which encodes alpha-synuclein, the protein that clumps in Parkinson’s disease) is a major risk factor for PD. Using next-generation...

  • Cognition Biomarkers, 2013
    Assessment of Plasma Glucosylceramides and Ceramides as Biomarkers of Cognitive Impairment in Parkinson's Disease

    Metabolism of the lipids glucosylceramide and ceramide is altered in Parkinson’s disease (PD). GBA mutations in this pathway, causing a build-up of glucosylceramide, increase the...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    Validating the Montreal Cognitive Assessment for the Diagnosis of Mild Cognitive Impairment in Parkinson's Disease

    Dementia affects up to 80 percent of Parkinson’s disease patients, and the prevalence of other dementias including Alzheimer’s disease is high in this age group. A need exists for...

  • Defining Cognitive Phenotypes of Parkinson’s Disease, 2011
    Neurochemical Correlates of Cognitive Phenotypes in PD

    Parkinson’s disease causes neurodegeneration in multiple subcortical nuclei, including substantia nigra, locus coeruleus, dorsal raphe nucleus, and nucleus basalis. Each of these...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    Cognitive Decline in Parkinson's Disease

    There are many studies on cognitive and behavioral alterations in Parkinson’s disease, but each of these investigations brought only a small piece of a large puzzle. Consequently...

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