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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Cognition Biomarkers, 2014
    miRNA Markers of Cognition

    Objective/Rationale:
    In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs...

  • Cognition Biomarkers, 2013
    Alpha-synuclein and Cognitive Decline in Parkinson’s Disease

    Objective/Rationale:             
    Variability in the SNCA gene (which encodes alpha-synuclein, the protein that clumps in Parkinson’s disease) is a major risk factor for PD. Using next-generation...

  • Cognition Biomarkers, 2013
    Assessment of Plasma Glucosylceramides and Ceramides as Biomarkers of Cognitive Impairment in Parkinson's Disease

    Objective/Rationale:
    Metabolism of the lipids glucosylceramide and ceramide is altered in Parkinson’s disease (PD). GBA mutations in this pathway, causing a build-up of glucosylceramide, increase the...

  • Cognition Biomarkers, 2013
    Insulin-like Growth Factor-1 and DAT Imaging as Biomarkers of Early Cognitive Impairment in Parkinson’s Disease

    Objective/Rationale:        
    Evidence supports that the protein insulin-like growth factor-1 (IGF-1) may be involved in cognitive deficits. An earlier study found that low serum IGF-1 levels...

  • Cognition Biomarkers, 2013
    [18F]flubatine: a novel biomarker of cognition in Parkinson's disease

    Objective/Rationale:
    Mild cognitive impairment and dementia are frequent symptoms of moderate to advanced Parkinson’s disease (PD). Brain positron emission tomography (PET) study findings confirm post...

  • Cognition Biomarkers, 2013
    Validation of Novel and Traditional Quantitative EEG Biomarkers

    Objective/Rationale:
    Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD....

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