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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Resource: Utilizing Samples from the Arizona Parkinson’s Di, 2012
    Preferential Loss of Serotonin Axon Subtypes in Depression in Parkinson's Disease

    Objective/Rationale:
    Depression occurs in Parkinson’s disease (PD) much more frequently than in the general population, and is a major factor contributing to decreased quality of life for affected...

  • Repositioning Drugs for PD, 2012
    Amitriptyline as a Dopamine Neuroprotective Therapy

    Objective/Rationale:
    The project proposes to repurpose the tricyclic antidepressant medication, amitriptyline (AMI), as a disease-modifying therapy for Parkinson’s disease (PD). AMI is an FDA-approved...

  • Therapeutic Pipeline Program, 2015
    Improving Access to Depression Care in Parkinson’s Disease: A Telehealth Approach

    Study Rationale:                   
    There is a critical need for treatments that address depression and barriers to care among the approximately 5 million people living with Parkinson’s disease (PD)...

  • PD Subtypes, 2007
    Prediction of Death, Dementia, Disability, Depression from the Time Course of UPDRS Motor Status

    Parkinson’s disease is progressive. Early on, its effects are relatively minor, affecting mainly movement and causing shaking of the limbs. Later on, serious events -- early death, dementia,...

  • Fast Track, 2001
    PET Neuroimaging Study of the Brain Serotonin Transporter in Parkinson's Disease: Relationship to Clinical Depression

    Approximately 40% of patients with Parkinson's disease (PD) suffer from depression, which in many cases is more disabling than the impairment of motor function. Since the original discovery by Oleh...

  • Clinical Intervention Awards, 2009
    MASTER PD: Magnetic Stimulation for the Treatment of Motor and Mood Symptoms of Parkinson's Disease: A Four-Center, Sham-Controlled, Parallel Group Study

    Objective/Rationale:
    To determine the efficacy and duration of benefit of noninvasive brain stimulation with repetitive transcranial magnetic stimulation (rTMS) to modulate brain activity in order to...

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