Skip to main content
Funded Studies

Novel Candidate against Alpha-synuclein for the Treatment of Parkinson’s Disease

Study Rationale:
The goal of this program is to develop a novel drug for Parkinson’s disease with a unique mechanism of action. We have a drug candidate that shows potential as an inhibitor of alpha-synuclein buildup. People with Parkinson's have clumps of the protein alpha-synuclein in brain cells, which researchers believe may lead to disease symptoms and progression. 

Hypothesis:
Our drug candidate is designed to inhibit alpha-synuclein protein aggregation and spread of pathology by blocking a receptor known as heparan sulfate glycosaminoglycan.

Study Design:
We will first confirm the therapeutic effect of our leading drug candidate in a pre-clinical model of Parkinson's disease. Then the drug candidate will be synthesized in larger quantities and undergo a series of tests to evaluate its drug-like properties, metabolic stability and toxic liabilities. We also plan to optimize the oral delivery of the drug.

Impact on Diagnosis/Treatment of Parkinson’s Disease:
Following the successful completion of these studies, we will have identified a safe and well-tolerated drug candidate. This candidate will be well-positioned for advancement toward Phase I studies. If successful, this project could yield a unique, disease-modifying approach to treat Parkinson's disease. 

Next Steps for Development:
Following these studies, we intend to continue pre-clinical studies. Such activities include optimization of dosing and route of administration, development of a clinical plan, and holding a meeting with the FDA. Completion of the activities in this award should position this project on the development pathway to be successful in moving into Phase I clinical trials.


Researchers

  • Paul Gregor, PhD

    Lexington, KY United States


  • Patrik Brundin, MD, PhD

    Grand Rapids, MI United States


Discover More Grants

Search by Related Keywords

Within the Same Program

Within the Same Funding Year

We use cookies to ensure that you get the best experience. By continuing to use this website, you indicate that you have read our Terms of Service and Privacy Policy.