The Fox Investigation for New Discovery of Biomarkers
BioFIND is an observational clinical study designed to discover and verify biomarkers of Parkinson's disease (PD). The study was carried out at eight academic sites in the United States. Recruitment began in 2012 and closed in March 2015. BioFIND collected clinical data and biospecimens, including blood and cerebrospinal fluid (CSF), in well-defined, moderately advanced people with PD and control volunteers.
BioFIND followed standardized data acquisition protocols to ensure tests and assessments conducted at multiple sites could be pooled. Data and samples acquired from study participants have been placed in a comprehensive Parkinson's database and biorepository and are available to the scientific community for research on novel PD biomarkers. The study aims to complement the†Parkinson's Progression Markers Initiative†to produce the most comprehensive and long-ranging dataset available for biomarker discovery work throughout the PD community.
Only with collaborative efforts such as BioFIND can we efficiently discover and verify biomarker candidates for PD. This study is sponsored by The Michael J. Fox Foundation for Parkinson's Research with support from the National Institute of Neurological Disorders and Stroke (NINDS).
Available Biospecimens and Data*
|Clinical Data||Whole Blood Pellet||Plasma||Saliva||Urine||DNA||RNA||CSF|
*Numbers refer to submission from unique individuals. Typical submissions include: clinical data, 2 whole blood pellets, 12 ml plasma from whole blood, 8.5 ml whole blood for DNA extraction, 5-10 ml whole blood for RNA extraction, 10 ml cerebrospinal fluid.
Accessing Clinical Data and Biospecimens
Clinical data and biospecimens from BioFIND are available for request. Clinical data from BioFIND is hosted by the study Bioanalytics Core, and applications for data access are reviewed in real time. Curated BioFIND data is available at†neuroshare.michaeljfox.org. Learn more on our†Accessing BioFIND Data†page.
To request access to available BioFIND biosamples, apply to the centralized NINDS Parkinson's biospecimens program. Learn more on our†Accessing BioFIND Biospecimens†page.
Direct questions to firstname.lastname@example.org.
The following research studies have been approved for sample use.
Ongoing Research Utilizing BioFIND Specimens
The following research studies have accessed BioFIND samples. Researchers may apply to use biospecimens through†NINDS .