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LRRK2 Cohort Consortium

The Michael J. Fox Foundation (MJFF) is pioneering an innovative approach around the LRRK2 gene in an effort to streamline and orchestrate drug development against this promising target for Parkinson's disease (PD) drug development.  The MJFF-led LRRK2 Cohort Consortium brings research groups together early on – sharing resources, troubleshooting common problems, and identifying best resources – to speed collective efforts to move LRRK2 toward practical therapeutic relevance for patients. 

The Consortium follows standardized data acquisition protocols to ensure that tests and assessments conducted at multiple sites can be pooled. Cross-sectional data and samples acquired from study participants are included in a comprehensive Parkinson's database and bio-repository, which is available to the scientific community to conduct research on novel PD biomarkers and will be updated on a quarterly basis throughout the duration of the study. The Consortium aims to complement PPMI to produce a comprehensive dataset available for biomarker discovery work throughout the PD community.

Learn more about participating  biofind eligibility

Learn more about study design biofind eligibility


Available Biospecimens and Data*

Clinical Data Whole Blood Plasma Serum RNA Urine CSF
Idiopathic PD 771 59 60 59 59 56 30
LRRK2+ PD subjects 811 147 147 147 148 117 28
LRRK2+ without PD 488 123 124 125 125 123 35
Controls (LRRK2-) 448 144 141 141 145 141 23

*Available resources as of September 30, 2013. Numbers refer to submissions from unique individuals. Typical submissions include: clinical data, 6 ml whole blood (frozen without processing), 10 ml whole blood for plasma, 10 ml whole blood for serum, 2.5 ml whole blood for RNA extraction, 10 ml urine; 10 ml cerebrospinal fluid.

For more information about processing and aliquoting refer to the Biologics Manual (US or Europe).

Recruitment is ongoing and sites continue to collect samples and clinical data.  The next cut of data and samples will be released on April 14, 2014.

View a list of publications and presentations utilizing the resources.

Access Data & Biospecimens

 

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