Research Tools PRIORITY AREA
Why Are Research Tools a Priority?
Researchers rely on critical tools, including reagents and pre-clinical models, to understand the cause and mechanisms underlying Parkinson's disease and to develop effective treatments. When such tools are lacking, investigators must often make their own, wasting time and resources that would be better spent on studying Parkinson's disease. Many existing tools may also lack sufficient quality control data, are difficult to obtain by the wider research community, or may come with restrictive license terms and fees that hinder drug makers' ability to use them. Promoting the generation and availability of critical research tools is a key way to accelerate therapeutic development for Parkinson's patients.
Our Investment in Research Tools
The Michael J. Fox Foundation has a multi-faceted approach to developing research tools:
- Identifying critical tools through discussions with key scientific experts
- Generating critical tools through partnerships with leading experts and companies
- Evaluating critical tools to provide reliable quality control data and to inform ideal methods for use
- Distributing critical tools, ideally through no/low-cost, restriction-free vendors and partner organizations, such as Addgene, Covance, Abcam, and The Jackson Laboratories
Employing this strategy, the Foundation has made a number of tools available to the research community, including DNA plasmids, viral vectors, purified protein, antibodies, assays and pre-clinical models.
In addition, the MJFF is spearheading the Parkinson's Disease Research Tools Consortium, working with industry partners to better characterize and utilize existing tools, as well as to develop new tools to address unmet challenges.
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Research Tools Consortium
MJFF is working with industry to characterize and develop tools.
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