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Funded Studies

Ricardo A. Feldman, PhD

Associate Professor at Department of Microbiology and Immunology, University of Maryland, Baltimore

Location: Baltimore, MD United States

Dr. Ricardo A. Feldman received his PhD from the Department of Cell Biology at New York University School of Medicine and did his postdoctoral work in Hidesaburo Hanafusa’s laboratory at the Rockefeller University, where he identified some of the first tyrosine kinase oncogenes captured by RNA tumor viruses. Dr. Feldman is now an associate professor in the Department of Microbiology and Immunology at the University of Maryland School of Medicine. His laboratory is using patient-derived induced pluripotent stem cells (iPSC) to study the molecular mechanisms by which mutations in lysosomal glucocerebrosidase cause GBA-associated neurodegeneration in Gaucher and Parkinson’s diseases. Using this system, his laboratory has recapitulated pathological hallmarks in the affected cell types, and identified key developmental and lysosomal pathways affected by GBA deficiency. His laboratory has developed sensitive assays to evaluate the therapeutic efficacy of drugs to treat Gaucher and GBA-associated Parkinson’s disease.


Associated Grants

  • Identification of Targets of Neurotoxic Sphingolipids Using iPSCs from People with GBA-associated Parkinson’s Disease

    2019


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