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Breaking News: A New Dyskinesia Drug Will Be Submitted to FDA This Year
September 21, 2016
… formulation of amantadine to better treat levodopa-induced dyskinesia is entering the home stretch. Its developer, … ADS-5102 compared with placebo, as assessed by the Unified Dyskinesia Rating Scale (UDysRS). The candidate was safe and … the company measured the impact of the drug using a new dyskinesia rating scale developed by Chris Goetz, MD, and …
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Fyn knockdown prevents levodopa-induced dyskinesia in a mouse model of Parkinson's disease
June 7, 2021
… often develop side effects, known as levodopa-induced dyskinesia (LID), that usually need therapeutic … exposure to assess its ability to prevent or revert dyskinesia. Pre-administration of miRNA-Fyn reduced LID with … miRNA-Fyn was less effective to revert already established dyskinesia, suggesting that early blocking of Fyn activity …
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The Parkinson’s Minute: Unified Dyskinesia Rating Scale Provides Common Yardstick for Drug Developers
June 1, 2012
… Could Speed Development of New Dyskinesia Treatments In this second edition of The … scale for measuring patient response to therapies to treat dyskinesia , the debilitating, uncontrollable movements that … past, clinicians used several different scales measuring dyskinesia, without any real evidence that they accurately …
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Addex Moving Forward with Phase II Study to Reduce Levodopa-induced Dyskinesia
September 27, 2011
… dipraglurant (ADX48621), in reducing levodopa-induced dyskinesia in patients with Parkinson’s disease (PD). The … blocking the action of mGluR5 prevented levodopa-induced dyskinesias in pre-clinical models of PD. MJFF research … supporting mGluR5 as a highly promising target to treat dyskinesia, Addex applied for a $900,000 grant from MJFF to …
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The Michael J. Fox Foundation Commits $2 Million to New Dyskinesias Research Program
February 7, 2003
… committed $2 million to a new research intiative to study dyskinesias, the involuntary, uncontrollable movements that … associated with Parkinson’s disease. The presence of dyskinesias is a major limiting factor in achieving adequate … of patients will develop uncontrollable movements, or dyskinesias, a major of disability in their lives. In …
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Too Much or Not Enough: Dyskinesia and ''Off'' Time in Parkinson's (Replay)
August 17, 2023
… Page Cancel Register for Webinar Too Much or Not Enough: Dyskinesia and ''Off'' Time in Parkinson's (Replay) First … pm ET We will replay a popular webinar on “off” time and dyskinesia. Our expert panelists discuss these common … time is when symptoms return between medication doses. Dyskinesia is uncontrolled, involuntary movement. We cover …