… This grant builds upon the research from a prior grant: Targeting the Unfolded Protein Response … characterized by impairment of motor control as a result from extensive neuron death. The primary mechanism … loss in PD remains unknown. Clues have been obtained from families who have a genetic form of PD that is …

… the conversion factor with which subjects can be switched from oral levodopa to DopaFuse, and ii) to determine … stabilized plasma levodopa concentrations. Positive results from the study will validate the feasibility of subcutaneous … Partnering Program Two-Pager Final Outcome Based on data from pre-clinical models, the route of administration and …

… This grant builds upon the research from a prior grant: Identification of Alpha-synuclein … synuclein and its processed forms (“alpha synucleome”) from minimal clinical model brain tissue using high … methods.  In total extracts of autopsied frontal cortex from Parkinson’s disease, Dementia with Lewy Bodies (DLB) …

… the E46K mutation of the alpha-synuclein gene in a family from the Basque region of Spain. The rare E46K mutation is … MRI and retinal OCT and compare those findings with results from matched participants from the control group. Lastly, we will look for imaging …

… We propose to analyze data on autonomic function collected from PD patients and relatives of PD patients both with … some autonomic symptoms.   Project Description: Four groups from the LRRK2 Cohort Consortium will participate in this … We will perform analysis of autonomic scores extracted from different standardized questionnaires. Using different …

… identify disease-specific modifications of alpha-synuclein from available CSF samples from PD patients and healthy controls at baseline and … amounts in CSF. With these assays, we will analyze samples from several other available cohorts to validate initial …