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Podcast: Levodopa Myths
February 12, 2019
… becomes less effective over time or that it always causes dyskinesia (involuntary, uncontrolled movements). Like any …
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Novel Gel Formulation of Parkinson's Drug May Limit "On/Off" Roller Coaster Ride
April 20, 2012
… the levodopa-induced motor complications of wearing off and dyskinesia may soon have another treatment option: A … effects wear off) and increased “on” time without dyskinesia. The Phase 3 results from this study are in line … time decreased by four hours a day, while “on” time without dyskinesia increased by more than four hours. The gel also …
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D-512: a Novel, Multifunctional D2/D3 Receptor Agonist for the Treatment of Parkinson’s Disease
… examined for motor performance, drug-induced rotations and dyskinesia. At the end of the study, we will verify dopamine … to have a low liability for drug-induced side effects like dyskinesia. Such findings implicate its potential as a novel …
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Development of Small Molecule Activators of Nurr1 as Potential Therapeutics for Parkinson's Disease
… side effects, including involuntary movements called dyskinesias. By enhancing survival of dopamine-producing … Nurr1 activation may boost dopamine levels without inducing dyskinesias. Next Steps for Development: We will continue …
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Newly Approved Parkinson’s Drug Aims to Lessen “Off” Time
April 27, 2020
… or with fewer of them. Possible side effects may include dyskinesia (involuntary movement), difficulty sleeping, … that aren’t there). Some possible complications, such as dyskinesia, may relate to the levodopa boost rather than a …
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Marc G. Caron, PhD
… at the dopamine D1 receptors can eliminate levodopa-induced dyskinesias. His proposed work is to develop a …