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Funded Studies

Marc G. Caron, PhD

James B. Duke Professor of Cell Biology at Duke University

Location: Durham, NC United States

Dr. Marc G. Caron is a James B. Duke Professor in Cell Biology at Duke University. His laboratory has worked in two main areas: around the largest class of receptors in the genome, the G protein-coupled receptors (GPCR), and in the family of neurotransmitter transporters. Over the years, the lab has engineered and characterized a large number of genetically modified models to understand underpinnings of various brain disorders. His laboratory was one of the first to demonstrate the idea that distinct signaling functions of GPCRs, like in dopamine receptors, have important physiological consequences. Recently, his laboratory has provided evidence that limiting the canonical G-protein signaling at the dopamine D1 receptors can eliminate levodopa-induced dyskinesias. His proposed work is to develop a small-molecule therapy to achieve this desirable result in humans.

Associated Grants

  • Managing Levodopa-induced Dyskinesias by Targeting Dopamine D1 Receptor Signaling


  • Validation of a Novel Pre-Clinical Model of Dyskinesia in PD


  • Targeting Beta-arrestin Signaling in the Treatment of Parkinson's Disease


  • Evaluation of the Role of Trace Amine 1 (TA1) Receptor in the Actions of Antiparkinsonian Drugs Using TA1 Receptor Knockout Mice


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