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Effects of Recombinant CDNF Protein in Alpha-synuclein Model of Parkinson’s Disease in Pre-Clinical Models
… test, as well tyrosine hydroxylase immunohistochemistry from striatum and substantia nigra, will be performed. CDNF … CDNF has a unique mode of action that dramatically differs from the mechanism of action of other neurotrophic factors. … of unfolded protein response pathways and rescues neurons from ER stress-induced cell death. CDNF can also act …
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Insulin-like Growth Factor-1 and DAT Imaging as Biomarkers of Early Cognitive Impairment in Parkinson’s Disease
… Description: This study uses samples available from participants in the Parkinson’s Progression Markers … study will be analysed for IGF-1 levels. DAT imaging data from the same subjects will be analyzed. Finally, scores obtained from neuropsychological tasks (Montreal Cognitive …
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Discovery of Changes in N-linked Glycans Associated with Parkinson’s Disease
… to discover PD-associated glycan changes in brain samples from pre-clinical models. Project Description: This study will analyze glycans isolated from brain stems of two PD models compared to control … reduction of dopaminergic neurons. Glycans will be released from their parent proteins and analyzed using the Glycan …
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Parkinson's Research Study Shows Inosine Compound Raises Urate Levels
December 23, 2013
… Foundation Funding New findings published in JAMA Neurology from research into a potentially protective therapy for … fluid (CSF) bathing the brain. SURE-PD grew out of results from two previous prospective studies that showed higher … to identify people at higher risk for PD, who may benefit from earlier intervention, and stratify clinical trials …
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Our Work in Washington, D.C. to Advocate for Parkinson’s Research Won’t Stop
June 12, 2020
… message was strengthened in early March, as 51 researchers from 28 states traveled to Capitol Hill for Researcher Hill … “Moving Parkinson’s science forward will require support from the federal government, much like what is happening … before a congressional subcommittee against a policy from the Environmental Protection Agency (EPA) that could …
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2019 by the Numbers: How MJFF’s Community Fundraisers Generated $11 Million in One Year
January 27, 2020
… portion of proceeds campaigns in 2019. Entrepreneurs from over 30 businesses — such as Sock it to PD , Squar’d … . More than 1,200 cyclists geared up for rides ranging from 10 to 70 miles in Atlanta, GA, Santa Rosa, CA, and Port … Ride on September 12. 1,000 musical minutes for a cure. From a multiple Grammy- and Latin Grammy-winning producer to …