The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2008Multiphosphatase Inhibitors as PD Therapeutics
Objective/Rationale:
Parkinson’s disease has multiple genetic and environmental causes. As a result, therapeutic efforts aimed at a single cause of the disease may have limited value. ShanaRx has... -
MJFF Research Grant, 2008Development of Lewy Bodies MRI Imaging Agents for the Early Diagnosis of Parkinson's Disease and Related Disorders
Promising Outcomes of Original Grant:
Parkinson’s disease and related conditions are the most common movement disorders. Pathological studies reveal abundant protein deposits in the affected neurons... -
Rapid Response Innovation Awards, 2008In Vivo Assessment of Alpha-Synuclein Secretion
Objective/Rationale:
The pathophysiological roles of the secreted AS forms remain largely unknown. We have identified oligomeric and monomeric AS species in the conditioned medium (CM) of SHSY5Y cells... -
Rapid Response Innovation Awards, 2008Structural Mapping and Drug Design for Prevention and Treatment of Parkinson's Disease
Objective/Rationale:
Drugs for treating Parkinson's disease have to date been identified by trial and error. We are using protein structure as a guide for identifying potential drug targets for... -
Rapid Response Innovation Awards, 2008A Pore-Based Method to Sort and Characterize Human Embryonic Stem Cell-Derived Dopaminergic Neurons
Objective/Rationale:
Although using human Embryonic Stem Cells (hESCs) as a clinical therapy for Parkinson’s disease is extremely promising, there exists a number of technical obstacles. In particular... -
Rapid Response Innovation Awards, 2008Calpain Inhibitors to treat Parkinsons Disease
Objective/Rationale:
Activation of the calcium activated protease, calpain, has been implicated in the initiation of the process of neuronal degeneration associated with PD. Thus, inhibition of...
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Our funding programs support basic, translational and clinical research from academia and industry.