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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • T2T Validation - Endolysosomal Targets, 2025
    Development of Translational Biomarkers for TRPML1 Target Engagement in Intact Whole Human Parkinson’s Disease Brains

    Study Rationale: TRPML1 is a promising drug target that offers the potential to slow the course of Parkinson’s disease. This study utilizes Bexorg’s revolutionary postmortem human brain platform to...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2025
    SNP614, A LRRK2 Antisense Oligonucleotide as Potential Therapeutic Agent for Parkinson's Disease

    Study Rationale: Parkinson’s disease (PD) is estimated to affect as many as 1 million Americans and up to 10 million people worldwide. The exact cause of PD is not yet fully understood, and currently...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2025
    Biomarker and IND-enabling Studies to Advance a CNS Penetrant GCase Activator for the Treatment of Parkinson’s Disease

    Study Rationale: The complexity of Parkinson’s disease (PD) has contributed to the poor success rate in drug development. At Neumora we seek to understand this complexity by identifying the biological...

  • Research Grant, 2025
    Powered Clothing and Wearable Robotics for Improved Gait, Balance and Reduced Freezing in Everyday Life

    Study Rationale: We’ve spent several years exploring the potential of supporting human movement with wearable robotics and we believe it has tremendous potential for the Parkinson’s community. With...

  • Research Grant, 2025
    A Comparative Performance Study between High and Standard Resolution Positron Emission Tomography Camera using [18F]AV-133 in Prodromal Parkinson’s Disease [Dual PET AV133 in Prodromal PD]

    Study Rationale: Parkinson’s disease (PD) is characterized by a prodromal phase long before someone presents with the clinical features of PD. During this phase, there are progressive biological...

  • Research Grant, 2025
    Clinical Development of 18F-RO7196581:A High-resolution PET Imaging Study Using NeuroExplorer

    Study Rationale: The primary objective of this study is to assess the feasibility and effectiveness of high-resolution PET imaging using the NeuroExplorer to visualize alpha-synuclein aggregation in...

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