The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2017Development of a Clinical Flow Cytometry Assay for Accurate and Selective Measurement of GBA1 Activity in Peripheral Blood Mononuclear Cells
Study Rationale:
A protein in the brain known as glucocerebrosidase may not work properly in those with Parkinson's disease (PD). Methods currently used to monitor the activity of this protein within... -
LRRK2 Therapeutic and Safety Initiative, 2017The Effects of a LRRK2 Inhibitor on Alpha-synuclein-induced Dopamine Deficits in a Pre-clinical Model of Parkinson's Disease
Study Rationale:
In a previous study, we demonstrated that PFE360, an LRRK2 inhibitor, has neuroprotective benefits. However, several questions remain unanswered as follows: (1) Did the vehicle... -
Research Grant, 2017Development of PET Tracers for Synucleinopathies
Promising Outcomes of Original Grant:
Our project aims to develop a brain imaging agent for alpha-synuclein, a key protein involved in Parkinson’s disease (PD) pathology. Such an agent will help (i)... -
Research Grant, 2017Inflammatory Parkinson's Clinical Biomarker Profiling
Study Rationale:
This study aims to compare the immune system of Parkinson's disease (PD) patients and their caregivers in an effort to determine differences between these groups. Several recently... -
Research Grant, 2017Using Neural Cells to Test New Drugs that Activate PINK1 and Parkin
Promising Outcomes of Original Grant:
Even though most people with Parkinson's disease (PD) do not have a genetic mutation -- a change in their DNA -- that causes the disease, genes can influence the... -
Research Grant, 2017Radioactive Molecules for Detection of Alpha-synuclein and Amyloid-beta in the Brain
Study Rationale:
We will develop radioactive alpha-synuclein and beta-amyloid tracers -- molecules that allow researchers and clinicians to detect these two proteins in the brain using imaging...
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Our funding programs support basic, translational and clinical research from academia and industry.