The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2009Characterizing Transgenic Pre-Clinical Models that Express a Mutant LRRK2 Gene Selectively in Adulthood
Objective/Rationale:
Mutations of the gene LRRK2 are identified in both familial and sporadic Parkinson’s disease (PD). How mutation of the LRRK2 gene causes neuronal dysfunction in PD remains to be... -
Postural Instability and Gait Disturbances, 2009Role of the Posterior Parietal Cortex and Pedunculopontine Nucleus in the Pathophysiology of Freezing of Gait: An MRI and TMS Study
Objective/Rationale:
Although disturbances in the posterior parietal cortex (PPC) and pedunculopontine nucleus (PPN) are thought to be involved in the development of freezing of gait (FOG) in PD... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009Development and Screening of Contrast Agents for In Vivo Imaging of PD
Objective/Rationale:
This project aims to develop reagents to image alpha-synuclein pathology in the brains of living patients as a PD specific biomarker.
Project Description:
Using a library of small... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009Utility of the Amyloid Ligand [18F]FDDNP in Human PET Imaging in Parkinson Disease
Objective/Rationale:
Biomarkers of Parkinson disease are sorely needed for the assessment of disease status so that they may be used to design more efficient and informative clinical trials of disease... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 200918F-labeled Alpha-Synuclein Ligands for PET Imaging of Lewy Bodies
Objective/Rationale:
The Avid-ProteoTech program aims at identifying radiopharmaceuticals for PET imaging of Lewy bodies in the human brain. Lewy bodies, formed by aggregates of alpha-synuclein, are a... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009A Strategy to Develop a Radiotracer Targeting Alpha-Synuclein
Objective/Rationale:
Alpha-synuclein is a protein that is found in nerve cells of patients with PD and therefore provides a potential target for methods designed to monitor the disease process in PD...
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Our funding programs support basic, translational and clinical research from academia and industry.