The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2024First-in-human Phase 1a Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending doses of SB-0110 after Oral Administration in Healthy Subjects
Study Rationale: Although levodopa is an effective treatment for Parkinson’s disease (PD), it has a debilitating on-target side effect of dyskinesia. An optimal PD therapy would selectively activate...
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Freezing of Gait Program, 2024Use of Neuromodulation to Relieve Gait Freezing in Parkinson’s Disease
Study Rationale: Almost all individuals with Parkinson’s disease (PD) develop episodes of freezing of gait, which is a sudden inability to take a step while walking. Gait freezing can cause falls that...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Study of Multiple Air Pollutants in Parkinson’s Disease (MAP-PD)
Study Rationale: Chemicals in our environment, including some air pollutants, likely contribute to the development of Parkinson’s disease (PD). However, relatively few chemicals have been identified...
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Accelerating Biological Understanding and Therapeutic Translation For Parkinson’s Disease- Biology, 2024Establishing a Cohort of Carriers with ATP13A2 Mutations for Clinical and Biomarker Analysis
Study Rationale: Polyamines are molecules that show neuroprotective effects, and one of the genes that is mutated in Parkinson’s disease (PD), ATP13A2, regulates cellular polyamine levels. Unpublished...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Investigating the Effects of Pesticide Exposure on Immune System Function in Parkinson’s Disease
Study Rationale: Although it is well known that exposure to environmental substances, including pesticides, contributes considerably to Parkinson’s disease (PD), the mechanisms are largely unexplored...
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ASAP CRN Competitive Renewal Opportunity, 2024Studying the Pathogenesis of Parkinson’s Disease Via Single-cell Analysis of Human Brain and Gut Cells: A Basis for Clinical Translation
Study Rationale: More than 100 regions of the chromosomes that we inherit from our parents show differences in DNA sequence between people with and without Parkinson’s disease (PD). Furthermore, as we...
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Our funding programs support basic, translational and clinical research from academia and industry.