The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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ASAP, 2023(SUPPLEMENT) Examining How Genes and Gut Bacteria Cooperate to Cause Parkinson’s Disease
Study Rationale: Recent studies suggest that the alpha-synuclein protein that forms aggregates in Parkinson’s disease (PD) may originate in the gut and travel along nerves that go to the brain...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Investigating the Molecular Basis of Neurodegeneration in GBA-associated Parkinson's Disease
Study Rationale: Mutations in GBA1, the gene that encodes the enzyme glucocerebrosidase (GCase), are among the most common genetic risk factor for the development of Parkinson’s disease (PD). GCase...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Discovering Ocular Biomarkers of Parkinson’s Disease
Study Rationale: Early detection of Parksinson’s disease (PD) leads to improved care and better quality of life. However, the current methods for diagnosing PD, physical examination and brain imaging...
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Lysosomal Biomarkers Program, 2023Development of Autophagy-lysosome Biomarkers for Parkinson’s Disease Using Stem Cell-derived Neurons and Biofluids
Study Rationale: Genetic, molecular, and pathological studies have highlighted the role of dysfunctional mechanisms for clearing cellular debris — called autophagy-lysosome pathways — in the...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Structure and Mechanism of PINK1-TOM Supercomplex Formation
Study Rationale: Mitochondrial dysfunction plays an important role in the development and progression of Parkinson’s disease (PD). In healthy cells, when mitochondria become damaged, protein called...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Evaluating the Impact of LRRK2 Mutation on Lysosomal Function in Macrophages
Study Rationale: Mutations in LRRK2 are associated with inherited forms of Parkinson’s disease (PD). LRRK2 is a lysosomal protein that is produced in immune cells, such as macrophages. These cells are...
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Our funding programs support basic, translational and clinical research from academia and industry.