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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Astrocyte Biology in Parkinson's Disease, 2019
    Control of Astrocyte Function by LRRK2

    Study Rationale:
    Mutations in the LRRK2 gene are known to cause Parkinson’s disease (PD), but how mutations in this gene lead to neuron death is not yet known. Astrocytes, which are brain cells that su...

  • Astrocyte Biology in Parkinson's Disease, 2019
    How Astrocytes Cause Neuronal Loss by Reacting to Alpha-synuclein

    Study Rationale:
    Research in Parkinson’s disease has largely focused on events that occur within neurons that are lost in disease. However far more abundant than neurons in the human brain are a type...

  • Astrocyte Biology in Parkinson's Disease, 2019
    Exploring Proteins associated with Alpha-synuclein in Astrocytes at Different Stages of Parkinson’s Disease

    Study Rationale:
    In addition to neurons, astrocytes are the other major cell type that have increased alpha-synuclein in Parkinson’s disease (PD). In fact, more astrocytes have increased alpha...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Mitochondrial Complex 1 PET Imaging in Parkinson’s Disease

    Study Rationale:
    Methods are needed for imaging early pathological changes in the brain. With such brain imaging, we would be able to determine whether medications are protecting against progression of...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Development of a Colony Stimulating Factor 1 Receptor (CSF1R) Radioligand for Imaging Microglia-selective Inflammation

    Study Rationale:
    We have shown that Parkinson’s disease has an underlying neuroinflammatory component that involves microglia, which are inflammatory and immune cells in the brain. We have developed an...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Multimodal MR Imaging of the Midbrain for Early Parkinson’s Progression

    Study Rationale:
    Parkinson’s disease (PD) is marked by the loss of dopamine neurons in part of the midbrain, a section toward the base of the brain that serves important functions in movement. In the...

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