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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Examining the Action of Potassium Channels and the Inflammasome in a Signaling Axis That Can Serve as a Pharmacological Target Against Parkinson’s Disease

    Study Rationale: Both voltage-gated potassium channels and inflammatory signaling are known to be involved in Parkinson’s disease (PD). Each of these signaling systems contributes to the brain...

  • Expanding Biological Understanding of PD, 2022
    Identifying Genes that Enhance the Activity of Glucocerebrosidase

    Study Rationale: Parkinson’s disease (PD) causes uncontrollable trembling, progressive rigidity of muscles and an inability to walk. We do not yet understand why certain people are more prone than...

  • Research Grant, 2022
    Development of Irreversible PET Radiotracers for Glucocerebrosidase

    Study Rationale: Glucocerebrosidase (GBA) is an enzyme that removes a sugar that is attached to certain fat molecules in the healthy brain. This critical biochemical process begins to malfunction...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Production of Preclinical Model of REM Sleep Behavior Disorder Using Alpha-synuclein Fibrils

    Study Rationale: REM sleep behavior disorder (RBD) is characterized by abnormal motor behaviors during the REM phase of sleep and is highly predictive of Parkinson’s disease (PD). A brain region...

  • Therapeutic Pipeline Program, 2022
    Developing Selective Ion Channel Blockers that Reduce Neuroinflammation in Parkinson’s Disease

    Study Rationale: We are developing novel therapeutics to reduce brain inflammation and enhance the survival and function of brain cells in Parkinson’s disease (PD). Studies over the past decade have...

  • Spring 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022
    Assessing Genetic Predisposition to Gastrointestinal Symptoms in Young-onset and Late-onset Parkinson’s Disease

    Study Rationale: Constipation is a common, nonmotor manifestation of Parkinson’s disease (PD) that can impact the quality of life of people with the condition. Yet little is known about the genetic...

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