The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Cell Replacement Therapy, 2004Combined Stem Cell Transplant & Growth Factor Therapy for PD
Cell replacement remains a viable option for Parkinson's disease. In the past few years, we and others have succeeded in producing large numbers of dopamine neurons from human embryonic stem cells, a...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Role of Nurr1 in survival, maintenance and function of midbrain dopamine neurons:Implications for disease intervention and therapy for PD
Nurr1 has been discovered as one of the key factors regulating survival and maintenance of midbrain dopamine neurons. Last year, Le and collaborators (Nature Genetics, 3:385, 2003) reported the...
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The Role of Inflammation in Parkinson's Disease, 2004The role of TNF-mediated dopaminergic neurotoxicity in Parkinson's disease: Novel anti-TNF biologics as biochemical tools and new therapeutic agents
In July 2004, at the one-year assessment of our initial grant under the Foundation's Inflammation initiative, we demonstrated that our novel dominant-negative TNFs offered significant in vivo...
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The Role of Inflammation in Parkinson's Disease, 2003Inflammatory Mechanisms & PD Risk: A Discordant Twin Pairs Case-Control Study
The cause of Parkinson’s disease is unknown. A genetic cause is identified in only a small percentage of cases. We believe that environmental factors play an important role in most cases of PD. While...
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Community Fast Track, 2003Regulation of Dopaminergic Pathways by Eph Family Receptors
Replacing dopaminergic neurons is an attractive alternative in the treatment of Parkinson's disease (PD). However, a successful treatment relies not only on the introduction of new neurons, but also...
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The Role of Inflammation in Parkinson's Disease, 2003Spiral Inflammation Hypothesis of Parkinson’ Disease
It is well known that autopsied brains from patients with Parkinson's disease (PD) show evidence of inflammation within the region of the brain thought to be responsible for PD â€" the substantia...
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Our funding programs support basic, translational and clinical research from academia and industry.