The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2003Mitochondrial Trafficking in Dopaminergic Neuron Injury
Mitochondria are considered to be the "power house" of all cells, including neurons, because they convert food into energy in the form that cells can use. When mitochondria fail, cells typically die...
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LEAPS, 2003High Resolution Whole Genome Study to Determine Genetic Loci of Parkinson's Disease
The Cox team will leverage Perlegen's high-density array technology and the Mayo Clinic's extensive patient database, clinical expertise and DNA bank to create a genetic map of causes and risk factors...
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Community Fast Track, 2002Proactive action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a pre-clinical model model of Parkinson's disease
Recently, in mouse studies the peroxisome proliferator-activated receptor-g (PPARg) agonist pioglitazone was shown to be effective in blocking the substantia nigra (SN) cell loss induced by MPTP in a...
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MJFF Research Grant, 2002Characterization of Alpha Synuclein in Human Fluids & Brain as a Biomarker for Parkinson's Disease
Dr. Michael Schlossmacher and his colleagues at Brigham and Women's Hospital are looking at levels of the protein alpha-synyclein in the blood as a possible biomarker for PD. Mutations in alpha...
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Cell Line, 2002Dopamine Neurons Derived from Human ES Cells
Embryonic stem (ES) cells proliferate extensively, and preliminary data show that animal ES cells can be manipulated to generate highly enriched populations of dopamine neurons that express genes...
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Cell Line, 2002Unlimited Numbers of Purified Midbrain Dopamine Neurons from Human Embryonic Stem Cells
The fact that dopamine (DA) cells are lost specifically but other nerve cells are still intact makes Parkinson's disease (PD) uniquely amenable to cell replacement therapy. Early attempts have...
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Our funding programs support basic, translational and clinical research from academia and industry.