The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Program-non-specific Funding, 2009Delivery of Kinase-Modified LRRK2 to Dopaminergic Neurons Using High-Capacity Viral Vectors
Promising Outcomes of Original Grant:
Mutations in LRRK2 are the most common known cause of PD, and LRRK2 demonstrates kinase-dependent neurotoxicity in vitro but these results have not been confirmed... -
Program-non-specific Funding, 2009Immunology and bio activity of regulated rAAV1-GDNF in pre-clinical models of PD
Objective/Rationale:
Clinical trials with a trophic factor called GDNF, where GDNF is injected directly in the brain by pumps, have not been completely successful. Many scientists believe that the... -
Program-non-specific Funding, 2009Time Course of TNF-alpha Expression and Oxidative Stress after Intrastriatal 6-OHDA
Objective/Rationale:
Animal models of Parkinson’s disease can provide investigators with tools to examine the causes of the disease itself as well as potential therapies for treatment. One of the most... -
MJFF Research Grant, 2008Developing New Antibodies for a Standardized Alpha-Synuclein Assay (ELISA)
Objective/Rationale:
To raise and characterize new antibodies in vertebrate animals that allow for the routine measurement of a key protein linked to Parkinson disease, alpha-synuclein. A renewable... -
Rapid Response Innovation Awards, 2008Development of modulators of alpha-synuclein conformation for PD therapeutics
Promising Outcomes of Original Grant:
Our Rapid Response Innovation Award (RRIA) enabled us to develop a conformational change assay for monomeric alpha-synuclein. We identified positive and negative... -
MJFF Research Grant, 2008Pharmacodynamic Biomarkers of Drug-induced Protein Clearance in Rodent Cerebrospinal Fluid
Objective/Rationale:
Parkinson’s disease is, at least in part, a disease caused by misfolding and aggregation of the protein alpha-synuclein. Boosting the natural degradation machinery of diseased...
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Our funding programs support basic, translational and clinical research from academia and industry.