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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Inhibiting Programmed Cell Death to Reduce Axonal Degeneration and Brain Inflammation in Parkinson´s Disease

    Study Rationale: The degeneration of neuronal axons is an early pathological feature of Parkinson’s disease (PD) and an attractive target for therapeutic intervention. We have demonstrated that a...

  • Research Grant, 2023
    Non-Invasive Method for Recovering Protein Biomarkers in Parkinson’s Disease

    Study Rationale: There is a need for simple methods to improve the diagnosis of Parkinson’s disease (PD) before individuals ever experience symptoms. Focused ultrasound technology can alter the walls...

  • Biomarkers to Support Therapeutic Trials Program, 2023
    Using the Chemical Modification of Alpha-synuclein to Define Disease State and Facilitate Patient Stratification in Parkinson’s Disease

    Study Rationale: Novel disease-modifying treatments for Parkinson’s disease (PD) are urgently needed as the prevalence of the disease is increasing and no cure is available. At this point, we have...

  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Targeting the Dopamine D1 Receptor for a Treatment of Parkinson’s Disease with Minimal L-DOPA-induced Dyskinesia

    Study Rationale: L-DOPA is the primary drug used for treating the mobility loss that occurs in Parkinson’s disease (PD) due to decreases in dopamine. Although L-DOPA enhances mobility, chronic...

  • Research Grant, 2023
    Evaluation of a Digital Therapeutics (DTx) Mobile App and Algorithm for Personalized Medication and Treatment Plan Optimization for People with Parkinson’s Disease

    Study Rationale: People with Parkinson’s disease (PD) have few options for keeping their symptoms under control. An app that could automatically monitor PD symptoms, like tremors, could allow users to...

  • Biomarkers to Support Therapeutic Trials Program, 2023
    Using Neurophysiology as a Stratification Tool for Synucleinopathy

    Study Rationale: Although numerous disease-modifying drugs are being developed for Parkinson’s disease (PD), the current methods used to identify people suitable for clinical trials are costly...

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