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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    A New Pharmaceutical Target for Mono and Add-on Therapy in Parkinson’s Disease

    Objective/Rationale:             
    We are targeting a molecule, for the first time in Parkinson’s research, that is only present in the human brain’s motor circuitry and that we believe will respond to...

  • Biosample and Tissue Resource, 2013
    From Genetic Risk Toward Genetic Prognosis

    Objective/Rationale: 
    The progression and prognosis of Parkinson’s disease (PD) varies considerably between individual patients — ranging from a manageable, functional decline to an aggressive course...

  • Research Grant, 2014
    Role of LRRK2 in Dopamine Modulation of Striatal Glutamate Transmission

    Objective/Rationale: 
    Many of the motor symptoms in Parkinson’s disease (PD) are attributed to a deficit of the neurotransmitter dopamine in the brain region called the striatum. Recent studies show...

  • Therapeutic Pipeline Program, 2014
    Development of a mGluR4 Therapeutic for Parkinson's Disease

    Study Rationale: 
    One of the major objectives for the development of new treatments for Parkinson’s disease is to find alternatives to the stimulation of the dopaminergic system through levodopa and...

  • , 2021
    Evaluating Patient-reported Outcome Assessment in Early Parkinson’s Disease

    Study Rationale: There are currently no validated tools for assessing functional changes in people at the earliest clinical stages of Parkinson’s disease (PD). Available approaches lack sufficient...

  • Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021
    Evaluation of “PDRepair,” a Novel Neuroprotective and Neurorestorative Therapeutic for GBA1-associated Parkinson’s Disease

    Study Rationale: Mutations in the GBA1 gene, which encodes an enzyme called GCase, is the strongest genetic risk factor for Parkinson’s Disease (PD) and most often results in the production of GCase...

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