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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2025
    A Meta-Analysis of Single Nucleus Allele Specific Expression to Investigate Parkinson's Disease

    Study Rationale: We will study “allele-specific expression” to understand how DNA variants relevant to Parkinson’s disease impact the expression of genes. By looking in each cell, we can check whether...

  • Research Grant, 2025
    Identifying and Pilot Testing Best Practices for Sharing Amyloid PET Research Information with Individuals Living with Lewy Body Diseases

    Study Rationale: Biomarkers are tests that measure something about a person’s health. Research studies often include biomarkers, but research participants may or may not receive the results. This...

  • Research Grant, 2026
    Multiscale Measurement of O-GlcNAc Changes in Parkinson’s Disease

    Study Rationale:                   

    Directly targeting the toxic aggregation of α-synuclein by drugs is very challenging. However, this protein is modified by different chemical groups that have the...

  • Spring 2025 RFA: Molecular MRI Biomarker Program, 2026
    Mapping Mitochondrial Dysfunction in Parkinson’s Disease Using 15N-Magnetic Resonance of Nicotinamide Metabolism (MiND15)

    Study Rationale:

    In Parkinson’s disease, one of the earliest problems in the brain is a failure of mitochondria—tiny structures that produce energy for cells. This energy failure happens before many...

  • Spring 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2026
    Bidirectional Genome-wide CRISPRi/a Screening Using Ratiometric GCase Substrates to Identify Genetic Modulators of Lysosomal GCase Activity

    Study Rationale:  

    Mutations in the gene GBA1, are the most common genetic risk factor for Parkinson Disease (PD)Mutations in GBA1 lead to malfunctioning of the protein glucocerebrosidase, which acts...

  • Spring 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2026
    Deciphering Intracellular Pathways Altered by LRRK2 Kinase Activity and Phospho-RAB Effector Function

    Study Rationale:                   

    Gain-of-function mutations in LRRK2 cause familial Parkinson’s disease (PD) and increase the risk of developing the sporadic form of the disease. However, how...

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