The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative -- Academic Track, 2008Identification of a novel calcium selective antagonist for neuroprotection in PD
Objective/Rationale:
The objective of the project is to identify a selective and potent antagonist for the Cav1.3 L-type calcium channel. These channels are thought to be responsible for the selective... -
Therapeutics Development Initiative -- Academic Track, 2008Structural and Chemical Approaches to Understand and Modulate LRRK2 Kinase Activity in Parkinson's Disease
Objective/Rationale:
Mutations in LRRK2 cause the most common familial forms, and some sporadic forms, of Parkinson’s disease. Considerable evidence indicates that the neurotoxicity of these LRRK2... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009Development and Screening of Contrast Agents for In Vivo Imaging of PD
Objective/Rationale:
This project aims to develop reagents to image alpha-synuclein pathology in the brains of living patients as a PD specific biomarker.
Project Description:
Using a library of small... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009Utility of the Amyloid Ligand [18F]FDDNP in Human PET Imaging in Parkinson Disease
Objective/Rationale:
Biomarkers of Parkinson disease are sorely needed for the assessment of disease status so that they may be used to design more efficient and informative clinical trials of disease... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 200918F-labeled Alpha-Synuclein Ligands for PET Imaging of Lewy Bodies
Objective/Rationale:
The Avid-ProteoTech program aims at identifying radiopharmaceuticals for PET imaging of Lewy bodies in the human brain. Lewy bodies, formed by aggregates of alpha-synuclein, are a... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2008Generation of Alpha-Synuclein Conformation Specific Aptamers for In Vivo Bioimaging of Alpha-Synuclein Pathology
Objective/Rationale:
Alpha-synuclein is an abundant brain protein, whose misfolding has been associated to the development of Parkinson’s disease. Visualization of the different misfolded forms of...
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Our funding programs support basic, translational and clinical research from academia and industry.