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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Translational Pipeline Program, 2022
    Prevention of Dementia in GBA-associated Parkinson’s Disease

    Study Rationale: Whereas motor symptoms can be well controlled by dopamine-enhancing drugs and deep brain stimulation, dementia represents a key milestone in the course of Parkinson’s disease (PD)...

  • Neuronal Synuclein Disease Endotypes 2024, 2025
    Development of Alpha-synuclein Seed Amplification Assay in Cerebrospinal Fluid as a Robust Biomarker of Synucleinopathies

    Study Rationale: Progressive aggregation of alpha-synuclein and the subsequent loss of affected brain cells starts 10 to 20 years before the onset of Parkinson’s disease (PD) symptoms. Early diagnosis...

  • Research Grant, 2017
    Blood Proteins for the Treatment of Parkinson’s Disease

    Study Rationale & Design:
    Components of blood have been found to improve health and enhance multiple biological functions in pre-clinical studies of age-related decline. Blood plasma has been...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Mitochondrial Complex 1 PET Imaging in Parkinson’s Disease

    Study Rationale:
    Methods are needed for imaging early pathological changes in the brain. With such brain imaging, we would be able to determine whether medications are protecting against progression...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Therapeutic Development of Novel STING Inhibitors to Treat Parkinson's Disease Neuroinflammation

    Study Rationale: Brain inflammation plays an important role in the pathology and progression of Parkinson’s disease (PD). One of the key proteins involved in this inflammatory process is STING...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients

    Objective/Rationale:
    The increase in impulsive and risky behaviors, like gambling, hyper-sexuality, and compulsive shopping are emotionally and financially devastating, and impose a significant burden...

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