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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Outcome Measures, 2021
    Assessing Parkinson’s at Home: Contactless Monitoring of Sleep, Motor Symptom Progression and Medication Response

    Study Rationale:
    The ability to accurately monitor Parkinson’s disease (PD) progression and medication response at home can significantly benefit disease management and drug development. In the past...

  • Therapeutic Pipeline Program, 2021
    Harnessing the ADAR Protein to Repair the LRRK2 Mutation Causing Parkinson's Disease

    Study Rationale:    
    The majority of cases of inherited Parkinson’s disease (PD) are caused by a single-letter change in the gene that encodes the LRRK2 protein. The mutation, which changes a G to an...

  • Therapeutic Pipeline Program, 2021
    Evaluating the Safety, Tolerability and Potential Efficacy of SB-0107 for Treating Parkinson’s Disease and Levodopa-Induced Dyskinesia

    Study Rationale:
    Although levodopa is an effective treatment for Parkinson’s disease (PD), its ability to activate dopamine D1 receptors also leads to its most vexing side effect: dyskinesia. An...

  • Therapeutic Pipeline Program, 2021
    Using Ketamine to Treat Depression in Parkinson’s Disease

    Study Rationale:
    Depression affects around half of people with Parkinson’s disease (PD). However, existing antidepressants are not effective in treating these symptoms in PD and new treatments are...

  • Analysis of Patient-Reported Outcomes from Fox Insight, 2021
    Overcoming Underrepresentation to Improve Generalizability in Fox Insight

    Study Rationale:
    Fox Insight is an online clinical study that surveys over 25,000 people with Parkinson disease (PD) about their overall health, symptoms and well-being. Unfortunately, certain...

  • Therapeutic Pipeline Program, 2021
    Targeting Brain-specific Stearoyl-CoA-Desaturase 5 (SCD5) as a Treatment for Parkinson’s Disease

    Study Rationale:
    Previous studies have shown that fat molecules called unsaturated fatty acids regulate the harmful effects that alpha-synuclein have on neurons. This protein forms a key part of Lewy...

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