To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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AAV1/2 A53T Alpha-Synuclein Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV1/2 A53T alpha-synuclein viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194242
AAV1/2 empty vector control
DNA Plasmids
Viral transgene plasmid used in the AAV empty vector control viral vector for the AAV A53T alpha-synuclein viral vector, both available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194243
AAV2/5 CBh WT Alpha-Synuclein Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV2/5 WT alpha-synuclein viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194244
Mouse Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of mouse monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_89075
Alpha-Synuclein KO Rat
Rat Model
Sprague Dawley rat strain with CRISPR/Cas9 genome targeting strategy to KO endogenous alpha-synuclein.
Generated as part of the Industry Tools Consortium.
Human Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of human monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_51486
AAV2/5 CBh Empty Vector Control
Viral Vector
Viral Vector (AAV2/5 serotype) to serve as a control vector for the AAV2/5-CBh-WT human alpha-synuclein viral vector. The AAV-CBh-empty vector plasmid is also available in the Plasmid section.
AAV2/5 Empty Vector Control
DNA Plasmids
Viral transgene plasmid used in the AAV empty vector control viral vector for the AAV WT human alpha-synuclein viral vector, both available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194245
Human/Rodent Alpha-Synuclein Aggregate ELISA
Assay
ELISA kit for the measurement of human and rodent alpha-synuclein aggregates.
Alpha-Synuclein 1-119 Truncation Antibody
Antibody
Rabbit monoclonal antibody specific for human/mouse alpha-synuclein truncated at the 119 residue. The antibody is compatible with slot blot, ELISA, and immunocytochemistry applications.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic