To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
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S69R Rab32 KI Mouse
Mouse Model
CRISPR/Cas9 genome targeting strategy to knockin S69R point mutation in the endogenous mouse Rab32 gene (corresponds to the S71R mutation in human Rab32).
PINK1 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout PINK1 on a Sprague Dawley rat background.
A2a-Flp Mouse*
Mouse Model
A2a-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Adora2a promoter and enable the targeting of Adora2a-expressing cells and the indirect pathway spiny projection neuronal (iSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
D1-Cre Mouse*
Mouse Model
D1-Cre knock-in express Cre recombinase from the mouse Drd1 promoter and enable the targeting of Drd1-expressing cells and the direct pathway spiny projection neuronal (dSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
D1-Flp Mouse*
Mouse Model
D1-FlpO knock-in expresses optimized Flp recombinase (FlpO) from the mouse Drd1 promoter and enables the targeting of Drd1-expressing cells and the direct pathway spiny projection neuronal (dSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
SYNJ1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CTSB for heterozygous and homozygous R219Q mutations.These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
A2a-Cre Mouse*
Mouse Model
A2a-Cre knock-in mice express Cre recombinase from the mouse Adora2a promoter and enable the targeting of Adora2a-expressing cells and the indirect pathway spiny projection neuronal (iSPN) subpopulation of neurons in the striatum. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Anxa1-Cre Mouse*
Mouse Model
Anxa1-Cre knock-in mice express Cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
DAT-Flp Mouse*
Mouse Model
DAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Conditional LRRK2 R1441G KI Mouse*
Mouse Model
Mice designed for conditional knockin of the LRRK2 R1441G mutation. Model was generated and deposited by Dr Dario Alessi at the University of Dundee through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Have questions or need additional information?
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic