… This grant builds upon the research from a prior grant: Investigation of the Contribution of …          We will continue our initial investigation of DNA from brains, looking specifically for mutations that have … of the alpha-synuclein gene in different regions of brains from PD patients and healthy controls. As we expect that …

… the Parkin protein. It is one of three genes that protect from young-onset Parkinson disease (PD); in Parkin's … will be validated using both human brain specimens (from young, aged healthy participants and participants with PD) and tissues from pre-clinical models carrying mutant genes linked to …

… This grant builds upon the research from a prior grant: Role of LRRK2 in Levodopa-induced … LRRK2 activity could worsen dyskinesia, but results from our pre-clinical study showed that increased production … that may regulate LRRK2 activity and protect cells from disease. We found that the loss of LRRK2 can worsen …

… that specific circular RNAs are present in biosamples from people with Parkinson's and not in biosamples from healthy people. These circular RNAs could be used to … by testing another set of samples, such as samples and data from the Parkinson's Progression Markers Initiative (PPMI), …

… range of studies spanning basic to clinical research, from cell replacement therapies and the circuitry to make it … Health to transform the Parkinson's Disease Research Agenda from a recommendation into an operational priority, and … Schneider, a Parkinson's patient and former radio announcer from Clinton, Iowa, and Audrey Penn, M.D., Acting Director …

… Results are in from a study of glial cell line-derived neurotrophic factor … could be due to placebo effect. Details on the study from Clare Wilson in  NewScientist : In the first stage of … J. Fox Foundation (MJFF)  supported earlier studies of GDNF from MedGenesis , the biotechnology company that developed …