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Trophic Factor Study Results: Placebo Effect?
March 1, 2019
… Results are in from a study of glial cell line-derived neurotrophic factor … could be due to placebo effect. Details on the study from Clare Wilson in NewScientist : In the first stage of … J. Fox Foundation (MJFF) supported earlier studies of GDNF from MedGenesis , the biotechnology company that developed …
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Deficit in Mitochondrial Transport as a Potential Measure of Parkinson's Disease
… movement takes place in human nerve cells derived from stem cells donated by people with PD and whether this … they move within the processes of nerve cells in vitro . From a repository of human induced pluripotent stem cells, …
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Interpretation of Accelerometer Data with Deep Learning
… that deep learning can extract important signals from gait records collected from wearable devices, which can be further correlated with … to each other. mPower data are much diversely sampled -- from more than 3,000 unique participants -- so we expect the …
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Studying GLP1 Receptor as a Therapeutic Target in Parkinson's Disease
… that people with Parkinson's disease (PD) benefited from the treatment with GLP1 agonist exenatide. How activation of the GLP1 receptor may protect cells from neurodegeneration will predict whether the GLP1 … inherited Parkinson's and identify people who may benefit from GLP1 agonists. Impact on Diagnosis/Treatment of …
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Functional Evaluation of Alpha-synuclein Dosage Effects in CRISPR‐edited SNCA Model
… grant was to develop a patient-derived stem cell model from skin cells with different expression levels of protein … in the alpha-synuclein gene. Differentiated neuronal cells from these cell lines showed differences in the composition … differentiated neuronal cultures in all cell lines ranging from no alpha-synuclein expression (0 functional …
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Activation of Transposable Elements as a Trigger of Neuroinflammation in Parkinson’s Disease
… elements, which are viral-like gene fragments left over from viral infections. While transposable elements are … whether transposable elements are active in tissues from patients with Parkinson’s disease and whether this … activity using single-cell RNA sequencing of tissues from people with Parkinson’s disease. This particular …