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Targeting GCase with Novel Pharmacological Chaperones
… several important cellular mechanisms and may contribute to neurodegeneration. To recover GCase activity, we propose to use small molecules called non-competitive pharmacological chaperones that specifically … results will be further tested in models of PD/GBA with the goal to ease PD symptoms and pathology. The final …
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What We Fund: $60.6M for Tools to Detect PD and Therapies to Treat It
June 27, 2025
… Michael J. Fox Foundation (MJFF) announces 69 grants that total $60.6 million awarded in April and May 2025. These … the gap between discovery research and clinical trials with the Therapeutics Pipeline Program . The program ensures … targeting mitochondria. More PPMI-driven research is coming, including from MJFF’s new PPMI Biofluid Biomarkers …
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'A Pathway' to Fight Parkinson's
March 2, 2010
… Editor's Note: Stay tuned for an MJFF News in context about … said Dr. Stanley Appel, a Texas researcher who is familiar with the UNMC work. A vaccine developed by UNMC researchers … neurons. The result is that the disease becomes worse. Injection of the vaccine produced cells that …
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What We Fund: $40.2M Toward Tools to Measure Parkinson’s and Therapies to Treat It
October 25, 2024
… Michael J. Fox Foundation (MJFF) announces 129 grants that total more than $40.2 million awarded in August and … PD 20 years ago, and they are now understood to be the most common causes of inherited PD. The mutations typically … drug to reduce LRRK2 activity using a less-studied approach with the hope that it retains beneficial effects while …
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'Back to the Future' Hoverboard Auction to Benefit The Michael J. Fox Foundation
July 25, 2013
… Ever wonder what it would be like to ride a real Hoverboard, just like Michael did in Back to the Future II ? While we may never have the technology to … (EST) so make sure you head over to www.hoverboardauction.com to get your bids in now! Sam Fox …
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Running to Tell His Story
November 21, 2012
… run of the entire Pacific Crest Trail in 2011 and his Hamptons Hundred Miler run this past July. Running for Team Fox … touched by the disease to share their personal experience with others. As an added incentive, biopharmaceutical company UCB, Inc. will donate $5, up to $60,000 to MJFF for …