The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Aligning Science Across Parkinson's, 2021Activity and Connectivity Drive Neuronal Vulnerability and Disease Progression in Parkinson’s Disease
Study Rationale:
Specific brain circuits that are highly melanized (build-up of the dark pigment neuromelanin) with age are primarily affected, particularly early, in Parkinson's disease. Models... -
Aligning Science Across Parkinson's, 2021Cortical Pathophysiology of Parkinsonism
Study Rationale:
The outer mantle of the brain, the cerebral cortex, plays a significant role in selecting and controlling movements. Changes in the activity of cortical neurons are key to disorders... -
Aligning Science Across Parkinson's, 2021Redefining Parkinson’s Disease Pathophysiology Mechanisms in the Context of Heterogeneous Substantia Nigra Neuron Subtypes
Study Rationale:
The motor symptoms of Parkinson's disease (PD) result from the degeneration of the dopamine producing neurons in a brain area called the substantia nigra pars compacta (SNc). Recent... -
Aligning Science Across Parkinson's, 2021Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease
Study Rationale:
Many people with Parkinson’s disease develop untreatable cognitive symptoms, including problems with attention, decision-making, and dementia at late stages of the disease, due to... -
Aligning Science Across Parkinson's, 2021Circuit Mechanisms for Dopamine Neuron Vulnerability and Resilience in Parkinson’s Disease
Study Rationale:
While neurodegeneration in Parkinson’s disease (PD) affects many cells, dopamine neurons are particularly vulnerable, and their loss drives many of the major motor difficulties in PD... -
Aligning Science Across Parkinson's, 2021Mapping the Modulatory Landscape Governing Striatal Dopamine Signaling and Its Dysregulation in Parkinson’s Disease
Study Rationale:
Nerve cells that produce the brain chemical dopamine die in people with Parkinson’s disease. These dopamine-producing nerve cells extend very long and thin fibers called axons that...
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Our funding programs support basic, translational and clinical research from academia and industry.