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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers, 2021
    Autoimmune Targeting of Mitochondria as a New Biomarker for Parkinson’s Disease

    Study Rationale:
    Parkinson’s disease (PD) is a complex, age-related disorder for which there are currently no biomarkers available to diagnose or predict the onset of disease. However, growing...

  • Research Grant Supplement, 2021
    The Role of LRRK2 in the Accumulation and Spread of Tau Protein

    Study Rationale:
    Although most cases of Parkinson’s disease (PD) have no known genetic cause, a subset is driven by mutations in a gene called LRRK2 (leucine-rich repeat kinase 2). Further, evidence...

  • Environmental Risk Factors, 2021
    Nationwide Geographic Cluster Analysis of Incident Parkinson’s Disease

    Study Rationale:
    The causes of Parkinson’s disease (PD) are mostly unknown, but non-genetic factors, such as environmental exposures during one’s lifetime, probably affect whether a person develops PD...

  • Environmental Risk Factors, 2021
    Exposure to Ambient Air Pollution and Risk of Parkinson’s Disease

    Study Rationale:
    Ambient (outdoor) air pollution can increase the risk of cardiovascular diseases and death. Some evidence links ambient air pollution to higher risk of Parkinson’s disease. But current...

  • Research Grant, 2021
    Use of LRRK2 and Lysosomal Biomarker Signatures to Differentiate Idiopathic and Monogenetic Parkinson’s Disease

    Study Rationale:    
    As new targeted therapies for Parkinson’s disease (PD) enter clinical trials, it will be important to develop biomarkers that will allow clinicians to match people with PD with...

  • Target Advancement Program, 2021
    Validating Genetic Modifiers that Affect Disease Onset in People with LRRK2 Mutations

    Study Rationale:
    Mutations in the LRRK2 gene are a genetic cause of Parkinson’s disease (PD). However, the disease risk for carriers of LRRK2 mutations varies widely. Other genes — or genetic...

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