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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Non-pharmacological Interventions for Gait and Balance, 2019
    Vibrating Socks: A Novel Cueing Intervention to Reduce Freezing of Gait in Parkinson's Disease

    Study Rationale:
    Freezing of gait is a common and disabling symptom in Parkinson's disease. With freezing of gait, patients have the feeling that their feet are suddenly glued to the floor when they...

  • Biomarkers of Protein Handling/Autophagy, Exosomes and Lipid, 2019
    Studying Blood Proteins to Improve Diagnosis and Tracking of Parkinson's Disease

    Study Rationale:
    Mutations (changes) in protein LRRK2 is the main genetic cause of Parkinson's disease (PD). In the past, we found that LRRK2 interacts with ribosomes, cellular protein factories. We...

  • Alpha-synculein Biology and Therapies, 2018
    Ordering the Earliest Neuronal Response Events to Native Alpha-synuclein Exposure

    Study Rationale:
    The protein alpha-synuclein forms aggregates in the brains of people with Parkinson’s. Here, we will not look at the end stage of protein aggregation and cell death, which has been...

  • Alpha-synculein Biology and Therapies, 2018
    Structure and Function of Alpha-synuclein at the Pre-synapse

    Study Rationale:
    Current therapeutic strategies against synucleinopathies aim to either stabilize a native form of alpha-synuclein or to reduce its levels in patients. However, the normal...

  • GBA Biology and Therapies, 2018
    Sphingolipid and Alpha-synuclein Interactions

    Study Rationale:
    In Parkinson’s, a normal cellular protein called alpha-synuclein begins to fold incorrectly (misfold), and this has a central role in the development of the disease. Our research...

  • Alpha-synculein Biology and Therapies, 2018
    Effects of Post-translational Modifications on Alpha-synuclein Aggregation

    Study Rationale:
    Evidence suggests that the protein alpha-synuclein can cause the death of neurons in the brains of people with Parkinson’s disease (PD) by forming clusters (or aggregates) on the...

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