The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2009Assessment of the Therapeutic Efficacy of Progranulin in a Sub-chronic Small Model of Parkinson's Disease
Objective/Rationale:
Progranulin (PGRN), a protein found in the brain, is thought to promote the survival and health of brain cells. Neurodyn Inc. has discovered PGRN to have disease-modifying effects... -
Therapeutics Development Initiative, 2009Validation of LRRK2 as a Drug Target for Treatment of Parkinson's Disease Using Antisense Technology
Objective/Rationale:
Missense mutations in leucine-rich repeat serine/threonine-protein kinase (Lrrk2) are linked/associated with dominantly inherited, late-onset Lewy body Parkinson's disease (PD)... -
Therapeutics Development Initiative, 2009Pre-clinical Development of a Parkinson's Disease Therapy Using a Glucagon-Like Peptide (GLP)-1 Receptor Agonist
Objective/Rationale:
The Glucagon-Like-Peptide-1 (GLP-1) receptor agonist, exendin-4 (exenatide injection; brand name Byetta) is an FDA-approved, first-in-class treatment for patients with Type 2... -
Therapeutics Development Initiative, 2009Distribution of a Dominant-negative Inhibitor of Tumor Necrosis Factor
Objective/Rationale:
The blood-brain barrier (BBB) allows only a small fraction of systemically administered small-molecule drugs and even fewer biopharmaceuticals developed for disorders of the... -
Therapeutics Development Initiative, 2009Optimising Lead Series of Small Molecule Inhibitors of LRRK2 to Deliver Tool Compounds and Clinical Development Candidates
Objective/Rationale:
The exciting discovery of activating mutations in the LRRK2 kinase in a subset of familial PD patients provides a route to better understanding of signaling pathways that, when... -
MJFF Research Grant, 2009Pre-clinical Knockout Models of Parkinson's Disease
Objective/Rationale:
The objective of this project will be to use Sigma’s novel CompoZr (TM) ZFN technology to genetically engineer five distinct pre-clinical models in which genes implicated in...
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Our funding programs support basic, translational and clinical research from academia and industry.